Results 131 to 140 of about 12,955,611 (331)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Frequency Response Modeling and Adaptive Integrated Inertia Control for Wind Farms Considering Wake Effect and Time-Delay Impact

Kongzhi Yu Xinxi Jishu
With the increasing penetration of wind power into power systems, its volatility and intermittency have brought severe challenges to stability in grid frequency.
ZHOU Tao, DU Keke
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Analysis of the Impact for Mixed Traffic Flow Based on the Time-Varying Model Predictive Control

Systems
The connected and automated vehicles (CAV) smoothing mixed traffic flow has gained attention, and a thorough assessment of these control algorithms is necessary.
Rongjun Cheng, Haoli Lou, Qi Wei
doaj   +1 more source

GUIDANCE LAW FOR IMPACT TIME AND ANGLE CONTROL WITH CONTROL COMMAND RESHAPING

Journal of the Korea Society for Industrial and Applied Mathematics, 2015
In this article, a more generalized form of the impact time and angle control guidance law is proposed based on the linear quadratic optimal control methodology. For the purpose on controlling an additional constraint such as the impact time, we introduce an additional state variable that is defined to be the jerk (acceleration rate).
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Modeling the impact of stress, caffeine, and sleep on reaction time in Moroccan air traffic control

Discover Psychology
Objective The study aimed to examine how caffeine intake during the day, sleep patterns, and perceived stress levels influence vigilance among Moroccan air traffic controllers (ATCs).
Manal Aich, Jamal El Aoufi, Ahmed Moussa
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Cooperative attack strategy during the terminal guidance phase for loitering munitions based on impact angle and impact time constraints

Xibei Gongye Daxue Xuebao
In order to solve the cooperative attack problem during the terminal guidance phase for loitering munition swarm, a cooperative attack strategy for loitering munitions with impact angle constraints is proposed.
ZHAO Junmin, WANG Ronggang, LI Xinguo, ZHANG Dong   +3 more
doaj   +1 more source