Results 201 to 210 of about 3,337,894 (247)

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Effectiveness of Lidocaine with Epinephrine Irrigation in Reducing Acute Pain from Surgical Removal of Mesioangular-Impacted Third Molars. [PDF]

Dent J (Basel)
Chatupos V, Apiphathanamontri M, Yuthavong S, Chatiketu P, Hutachok N, Srichairatanakool S.   +5 more
europepmc   +1 more source

A Novel Minimal Access Technique for Removal of Impacted Third Molars using Lasers - SMAL Technique.

J Pharm Bioallied Sci, 2022
Sunil PM, Panicker P, Nair VS, George L, Gopinath KA, Vishnudas P.   +5 more
europepmc   +1 more source

Multiscale Regulation of Ru‐Based Catalysts for Upgrading Biomass‐Derived Levulinic Acid and Levulinates to γ‐Valerolactone: Mechanisms, Advances, and Challenges

Advanced Science, EarlyView.
This review summarizes recent advances in the mechanistic, thermodynamic, and kinetic studies of biomass‐derived levulinic acid/levulinates conversion to γ‐valerolactone, along with the corresponding multiscale regulation strategies of Ru‐based catalysts.
Xin Ni, Cailu Xiao, Gongbing Zhou, Jingzi Zhang   +3 more
wiley   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Histopathological Changes of Dental Follicles of Impacted Third Molars in Ibb Governorate. [PDF]

Cureus
Al-Dumaini MS, Abbas AM.
europepmc   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source

The Role of Dental Arch Dimensions and Impacted Third Molars on Mandibular Anterior Segment Crowding. [PDF]

Eur J Dent
Selmani M, Bukleta MS, Duci SB.
europepmc   +1 more source

An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling

Advanced Science, EarlyView.
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen, Alexander Chen, Quincy Lyons, Van K. Ninh, Maxwell C. McCabe, Colin Luo, Benjamin D. Bridgelal, Connor Uhre, Julian Cheng, Kate E. Reimold, Selena Cao, Kirk C. Hansen, Kevin R. King, Karen L. Christman   +13 more
wiley   +1 more source

Comparative Evaluation of the Flap and Flapless Techniques for the Extraction of Impacted Third Molars Using a Split-Mouth Prospective Randomized Control Research. [PDF]

J Pharm Bioallied Sci
Karpe T, Qureshi MY, Shaik SB, Nasyam FA, Kavya P, Harika TS.   +5 more
europepmc   +1 more source