Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Dones i transmissió lingüística en llars d’origen immigrant . Impactes, reptes i oportunitats
És reconegut que les pràctiques lingüístiques en el context familiar tenen un paper clau perquè una llengua sigui o no transmesa de pares a fills. En les llars d’origen immigrant amb infants i joves escolaritzats en català, la reproducció d’aquesta ...
Paquita Sanvicén-Torné
doaj
L’OMS sur la trace vers le réservoir animal du Sars-CoV-2. [PDF]
Manus JM.
europepmc +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Sustentabilidade ambiental e humana da produção de alimentos: uma análise comparativa entre agricultura biológica e convencional [PDF]
A produção e o consumo de alimentos produzidos em agricultura biológica (AB) apoiam-se na ideia da sua superior qualidade nutricional e em supostos efeitos benéficos na saúde humana, bem como no menor impacto ambiental da AB relativamente à agricultura ...
Duarte, Amílcar +2 more
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Línies de treball per a una política catalana en R+D+i en prevenció de residus [PDF]
Malgrat que la prevenció de residus és la prioritat formal de les polítiques de gestió de residus, mai no s'ha desplegat un pla de R+D+I coherent i amb prou recursos econòmics; de fet, la previsió és que el PROGREMIC (207-2012) destini només un 0,7% del ...
Garcia, Rosa +2 more
core
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Aplicação do sistema de avaliação SBToolPT-H na otimização da sustentabilidade de um caso de estudo em Guimarães [PDF]
O contexto presente alerta para a necessidade de repensar o atual modelo de consumo: a escassez de alguns recursos naturais, nomeadamente combustíveis fósseis e matérias-primas, e a consequente escalada de preços, tornam-se insustentáveis tanto a nível ...
Bragança, L. +5 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

