Results 111 to 120 of about 40,291 (312)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Femoral impaction bone grafting in revision hip arthroplasty: 705 cases from the originating centre

, 2016
In 1987, femoral impaction bone grafting was developed using morselised, cancellous bone graft impacted into the femoral canal in combination with a cemented, tapered, polished stem.
Wilson, M.J., Gie, Graham, Wilson, Matthew J., Timperley, A.J., Whitehouse, S. L., Hook, S., Timperley, Andrew J., Whitehouse, S.L., Gie, G.A.   +8 more
core   +1 more source

Wax Impaction in Nigerian School Children.

, 2011
Background: Impacted wax has been classified as an ear disease. It can cause pain, itch­ing, tinnitus hearing loss or otitis externa. The prevalence of cerumen impaction varies.
Ezeanolue, BC, Eziyi, J.A.E., Amusa, YB, Eziyi, JAE, Nwawolo, C.C., Nwawolo, CC, Ezeanolue, B.C., Amusa, Y.B.   +7 more
core   +3 more sources

Impact energy during cadaveric transforaminal lumbar interbody fusion (TLIF) is replicated by a modular benchtop device

Frontiers in Medical Engineering
In the treatment of intervertebral disc pathologies, lumbar interbody fusion (LIF) involves the removal and replacement of the degenerative disc with an interbody fusion device (IFD).
Caitlin Luke, Micah Foster, Alexis Graham, Tanner Jones, Halleigh Faulkner, Alyna-Marie Janus, Clark Hensley, Jerald Redmond, MeLeah A. Henson, Lauren B. Priddy, Matthew W. Priddy   +10 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Successful Resolution of Fecal Impaction During Endoscopy Using a Looped Guidewire [PDF]

Fecal impaction is the impaired excretion of a large fecal mass, and mild cases are treated by enema and osmotic laxatives. However, treatment-resistant cases need more invasive alternatives. A woman in her 60s presented with abdominal discomfort.
100001541, Yanagitani, Atsushi, Isomoto, Hajime, 90322304, 16723, 磯本, 一, Hashimoto, Takeshi, 1082, Okada, Tomoyuki, 16725, イソモト, ハジメ, 16724   +11 more
core   +1 more source

Impact [PDF]

F&S Reports, 2020
Olivia Carpinello, MD, Alan DeCherney, MD   +1 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Clinical results : Acetabular impaction grafting

, 2010
Written by the surgeons of the Exeter Hip Team and their colleagues from around the world, this book describes 40 years of innovation and development with cemented hip replacement.
Rigby, Michael, Whitehouse, Sarah L., Timperley, A. John   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source