Results 161 to 170 of about 40,291 (312)

Penatalaksanaan Multiple Impaction dengan Menggunakan Alat Ortodontik Interseptif

, 2018
Pendahuluan. Sebuah gigi impaksi akan meningkatkan kompleksitas dalam perawatan ortodontik, dan multiple impaction dapat mempersulit serta memperpanjang waktu perawatan secara keseluruhan.
Sasmita, Inne Suherna, Dini, Fitri Intan
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The impact and deformation of press-fit metal acetabular components

, 2012
PhDEarly failure of some metal-on-metal (MoM) hip implants are extensively reported but not fully explained. These arthroplasties commonly utilise large-diameter, thin-walled acetabular cups that have the advantage of minimal removal of acetabular bone ...
Hothi, Hardip Singh
core  

Mandibular Arch Morphology in Normodivergent Patients With Impacted Maxillary Canines: A Case-Control Study. [PDF]

Int J Dent
Lorusso M, Tepedino M, Marra LP, D'Angelo E, Esperouz F, Lo Russo L, Ciavarella D.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Small-Bowel Impaction Caused by Mechanical Interlocking Between Duodenal Metal and Biliary Plastic Stents. [PDF]

DEN Open
Otagiri S, Sugiura R, Wada M, Nomura A, Egami H, Wakabayashi K, Fujihata K, Katsurada T, Hirano S, Sakamoto N.   +9 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

PHAGE Impact and the Impact of Phages

PHAGE: Therapy, Applications, and Research, 2023
Martha, Clokie, Thomas, Sicheritz-Pontén   +1 more
openaire   +2 more sources

Association between mandibular third molar impaction patterns, second molar caries, and pericoronitis: a cross-sectional study in a syrian population. [PDF]

Saudi Dent J
Hadla E, Kuraitby S, Hasan MA.
europepmc   +1 more source