Results 101 to 110 of about 595,325 (257)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The impacts of war on health, human rights, and the environment—an overview

Frontiers in Public Health
War adversely affects health, violates human rights, and contaminates the environment. Direct health impacts of war result mainly from explosive weapons.
Barry S. Levy
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A Rapid Review of Territorialized Food Systems and Their Impacts on Human Health, Food Security, and the Environment. [PDF]

Nutrients, 2021
Rochefort G, Lapointe A, Mercier AP, Parent G, Provencher V, Lamarche B.   +5 more
europepmc   +1 more source

Economic Impacts on Human Health Resulting from the Use of Mercury in the Illegal Gold Mining in the Brazilian Amazon: A Methodological Assessment. [PDF]

Int J Environ Res Public Health, 2021
de Bakker LB, Gasparinetti P, de Queiroz JM, de Vasconcellos ACS.   +3 more
europepmc   +1 more source

Microscopic Menaces: The Impact of Mites on Human Health

International Journal of Molecular Sciences
Mites are highly prevalent arthropods that infest diverse ecological niches globally. Approximately 55,000 species of mites have been identified but many more are yet to be discovered. Of the ones we do know about, most go unnoticed by humans and animals. However, there are several species from the Acariformes superorder that exert a significant impact
Christina Linn, Andrea O’Malley, Kriti Khatri, Elaine M. Wright, Dylan Sebagh, Miodrag Grbić, Krzysztof Kowal, Maksymilian Chruszcz   +7 more
openaire   +4 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A critical review on the impacts of β-glucans on gut microbiota and human health

The Microbe
This review compiles current evidence on the effects of β-glucans on gut microbiota and human health, focusing on their structural properties, sources, and roles as a dietary fiber.
Great Iruoghene Edo, Alice Njolke Mafe, Ali B.M. Ali, Patrick Othuke Akpoghelie, Emad Yousif, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Khalid Zainulabdeen, Joseph Oghenewogaga Owheruo, Arthur Efeoghene Athan Essaghah, Huzaifa Umar, Dina S. Ahmed, Ahmed A. Alamiery   +12 more
doaj   +1 more source

Plastic residues produced with confirmatory testing for COVID-19: Classification, quantification, fate, and impacts on human health. [PDF]

Sci Total Environ, 2021
Celis JE, Espejo W, Paredes-Osses E, Contreras SA, Chiang G, Bahamonde P.   +5 more
europepmc   +1 more source