Results 101 to 110 of about 571,556 (258)

The impacts of war on health, human rights, and the environment—an overview

Frontiers in Public Health
War adversely affects health, violates human rights, and contaminates the environment. Direct health impacts of war result mainly from explosive weapons.
Barry S. Levy
doaj   +1 more source

A Rapid Review of Territorialized Food Systems and Their Impacts on Human Health, Food Security, and the Environment. [PDF]

Nutrients, 2021
Rochefort G, Lapointe A, Mercier AP, Parent G, Provencher V, Lamarche B.   +5 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Economic Impacts on Human Health Resulting from the Use of Mercury in the Illegal Gold Mining in the Brazilian Amazon: A Methodological Assessment. [PDF]

Int J Environ Res Public Health, 2021
de Bakker LB, Gasparinetti P, de Queiroz JM, de Vasconcellos ACS.   +3 more
europepmc   +1 more source

Plastic residues produced with confirmatory testing for COVID-19: Classification, quantification, fate, and impacts on human health. [PDF]

Sci Total Environ, 2021
Celis JE, Espejo W, Paredes-Osses E, Contreras SA, Chiang G, Bahamonde P.   +5 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Microscopic Menaces: The Impact of Mites on Human Health

International Journal of Molecular Sciences
Mites are highly prevalent arthropods that infest diverse ecological niches globally. Approximately 55,000 species of mites have been identified but many more are yet to be discovered. Of the ones we do know about, most go unnoticed by humans and animals. However, there are several species from the Acariformes superorder that exert a significant impact
Christina Linn, Andrea O’Malley, Kriti Khatri, Elaine M. Wright, Dylan Sebagh, Miodrag Grbić, Krzysztof Kowal, Maksymilian Chruszcz   +7 more
openaire   +4 more sources

A critical review on the impacts of β-glucans on gut microbiota and human health

The Microbe
This review compiles current evidence on the effects of β-glucans on gut microbiota and human health, focusing on their structural properties, sources, and roles as a dietary fiber.
Great Iruoghene Edo, Alice Njolke Mafe, Ali B.M. Ali, Patrick Othuke Akpoghelie, Emad Yousif, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Khalid Zainulabdeen, Joseph Oghenewogaga Owheruo, Arthur Efeoghene Athan Essaghah, Huzaifa Umar, Dina S. Ahmed, Ahmed A. Alamiery   +12 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source