Results 71 to 80 of about 73,972 (294)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Tunable impedance matching networks based on phase-switched impedance modulation [PDF]

2017 IEEE Energy Conversion Congress and Exposition (ECCE), 2017
The ability to provide accurate, rapid and dynamically-controlled impedance matching offers significant advantages to a wide range of present and emerging radio-frequency (RF) power applications. This work develops a new type of tunable impedance matching networks (TMN) that enables a combination of much faster and more accurate impedance matching than
Jurkov, Alexander, Radomski, Aaron, Perreault, David J   +2 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Design of X-Band GaN LNA MMIC with Switched Impedance Network for Improved Noise Figure [PDF]

Journal of Electromagnetic Engineering and Science
In this work, an X-band gallium nitride (GaN) low-noise amplifier (LNA) monolithic microwave integrated circuit (MMIC) with a switched impedance network for improved noise performance is designed and fabricated using a 0.25 μm GaN WIN-semiconductor ...
Byeong-Uk Lee
doaj   +1 more source

Dual-Band RFID Tag Antenna Based on the Hilbert-Curve Fractal for HF and UHF Applications [PDF]

, 2016
A novel single-radiator card-type tag is proposed which is constructed using a series Hilbert-curve loop and matched stub for high frequency (HF)/ultra high frequency (UHF) dual-band radio frequency identification (RFID) positioning applications.
Alibakhshikenari, Mohammad, Limiti, Ernesto, Naser-Moghadasi, Mohammad, Sadeghzadeh, Ramazan Ali, Virdee, Bal Singh   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Planar compact array with parasitic elements for MIMO systems [PDF]

, 2011
A compact planar array with parasitic elements is studied to be used in MIMO systems. Classical compact arrays suffer from high coupling which makes correlation and matching efficiency to be worse.
Haro Ariet, Leandro de, Puente García, David   +1 more
core   +1 more source

Modeling of a Cantilever-Based Near-Field Scanning Microwave Microscope

, 2008
We present a detailed modeling and characterization of our scalable microwave nanoprobe, which is a micro-fabricated cantilever-based scanning microwave probe with separated excitation and sensing electrodes. Using finite-element analysis, the tip-sample
K. Lai, M. Kelly, Palmer R. C., Tabib-Azar M., W. Kundhikanjana, Z. X. Shen   +5 more
core   +1 more source

A fully bidirectional 2.4-GHz Wireless-Over-Fiber system using Photonic Active Integrated Antennas (PhAIAs) [PDF]

, 2007
This paper describes a low-cost scheme for implementing in-building distributed antenna systems using the photonic-active-integrated-antenna (PhAIA) concept, whereby photonic devices are integrated directly with planar antennas.
Cryan, MJ, Sittakul, V
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source