Results 111 to 120 of about 347,752 (281)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Anemia Diagnostic System Based on Impedance Measurement of Red Blood Cells. [PDF]

Sensors (Basel), 2021
Cho H, Lee SR, Baek Y.
europepmc   +1 more source

Designing of a variable frequency standalone impedance analyzer for in vitro biological applications [PDF]

, 2014
Maximum biological samples have some electrical property, which gave us a new dimension in the field of biomedical engineering. Now-a-days measurement of impedance by applying an electrical voltage/current, has a broader application for analyzing ...
Sahoo, Saikat
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement. [PDF]

Nat Commun, 2021
Chin AL, Jiang S, Jang E, Niu L, Li L, Jia X, Tong R.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Combined multi-channel intraluminal impedance measurement and pHmetry in the detection of gastroesophageal reflux disease in children with cystic fibrosis. [PDF]

J Pediatr (Rio J), 2023
Gonçalves EDS, Ribeiro JD, Marson FAL, Montes CG, Ribeiro AF, Mainz JG, Toro AADC, Zamariola JH, Borgli DSP, Lomazi EA, Servidoni MFCP.   +10 more
europepmc   +1 more source

Near Source Acoustical Particle Velocity Measurements with Ambient Noise [PDF]

, 2007
An acoustical measurement very near a structure can be a cheap alternative to other contactless vibration measurement techniques such as laser vibrometry.
Boer, A. de, Philippens, D.R., Wind, J.W.   +2 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Novel Method of Estimating Iron Loss Equivalent Resistance of Laminated Core Winding at Various Frequencies

Energies
Electromagnetic and magnetic devices are increasingly prevalent in sectors such as transportation, industry, and renewable energy due to the ongoing electrification trend.
Maxime Colin, Thierry Boileau, Noureddine Takorabet, Stéphane Charmoille   +3 more
doaj   +1 more source