Results 31 to 40 of about 8,186 (267)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Symmetric Reconstruction of Functional Liver Segments and Cross-Individual Correspondence of Hepatectomy

Diagnostics, 2021
Accurate localization and analyses of functional liver segments are crucial in devising various surgical procedures, including hepatectomy. To this end, they require the extraction of a liver from computed tomography, and then the identification of ...
Doan Cong Le, Jirapa Chansangrat, Nattawut Keeratibharat, Paramate Horkaew   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Local mobility variations along recrystallization boundaries

Materials & Design
Understanding recrystallization boundary migration mechanisms is crucial for materials design. However, the lack of comprehensive mobility data for high-angle grain boundaries in typical polycrystalline samples has impeded gaining insights into the ...
Jin Zhang, Yubin Zhang
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Podemos: ¿regeneración democrática o impugnación del orden? Transición, frontera política y democracia

Cahiers de Civilisation Espagnole Contemporaine, 2016
Spanish politics has been shaken by the emergence of Podemos. This paper poses the question of whether Podemos represents a democratic regeneration or a refutation of order.
Javier Franzé
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tuning phonon transport spectrum for better thermoelectric materials

Science and Technology of Advanced Materials, 2019
The figure of merit of thermoelectric materials can be increased by suppressing the lattice thermal conductivity without degrading electrical properties.
Takuma Hori, Junichiro Shiomi
doaj   +1 more source

Miniaturization and Model-Integration of the Optical Measurement System for Temperature-Sensitive Paint Investigations

Sensors, 2023
The temperature-sensitive paint (TSP) method, an optical measurement technique, is used for qualitative skin friction visualizations in a wide variety of aerodynamic applications.
Jonathan Lemarechal, Benjamin Daniel Dimond, Hans Peter Barth, Michael Hilfer, Christian Klein   +4 more
doaj   +1 more source

On the Simultaneous Recovery of Boundary Impedance and Internal Conductivity

SIAM Journal on Applied Mathematics
Consider an inverse problem of the simultaneous recovery of boundary impedance and internal conductivity in the electrical impedance tomography (EIT) model using local internal measurement data, which is governed by a boundary value problem for an elliptic equation in divergence form with Robin boundary condition. We firstly express the solution to the
Jinchao Pan, Jijun Liu
openaire   +2 more sources