Results 61 to 70 of about 7,214 (264)

Influence Mechanism of Structural Parameters of a Novel Sleeve‐Shaft Counterrotating Hydrodynamic Cavitation Reactor on Cavitation Characteristics and Performance

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This study systematically investigates the cavitation characteristics of a novel sleeve‐shaft counterrotating (SSCR) hydrodynamic cavitation reactor using computational fluid dynamics (CFD). Based on the RANS framework combined with the SST k–ω turbulence model and the Zwart–Gerber–Belamri cavitation model, the temporal–spatial evolution of ...
Sitong Guan, Yongxing Song, Peng Zhuang, Jiahui Wang, Zhaoxin Ma, Yi Ge, Weibin Zhang, Jingting Liu   +7 more
wiley   +1 more source

Controllability and Observability Conditions for Impulsive DAEs on Time Scales

Asian Journal of Control, EarlyView.
ABSTRACT This paper establishes criteria for controllability and observability in a class of linear time‐invariant impulsive differential‐algebraic equations (DAEs) defined on a time scale. Controllability is defined as the ability to transfer the system state from any initial condition to any desired state within a finite time interval using an ...
Awais Younus, Zoubia Dastgeer, Thabet Abdeljawad, Meriem Louafi   +3 more
wiley   +1 more source

Experimental Studies on the Effects of Process Parameters on Granule Properties in a Conical High Shear Granulator [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2013
Experimental work was carried out to investigate the influence of impeller speed, granulation time, binder mass and their interactions on granule size distribution, mean size and binder content distribution in a conical high shear granulator.
Sima Ranjbarian, Fathollah Farhadi
doaj  

A Method for Optical Quantification of Local Oxygen Limitations in Multiphase Bioreactors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Spatial oxygen limitation is a major source of physiological stress and metabolic, scale‐dependent heterogeneity in aerobic bioprocesses. In gas‐liquid stirred tank reactors, oxygen availability is governed by hydrodynamics and mass transfer and is therefore inherently non‐uniform.
Ryan Rautenbach, Katharina Zörner, Jonas Barczyk, Marko Hoffmann, Ralf Takors, Michael Schlüter   +5 more
wiley   +1 more source

Research on optimization methods for large-flow coefficient centrifugal compressors

Frontiers in Energy Research
The present paper focuses on the optimization of large-flow coefficient centrifugal compressors, utilizing a mature centrifugal compressor impeller with a flow coefficient of 0.16 under design point condition in engineering as the research subject.
Changzhu Yang, Changzhu Yang, Liyun Fan, Shuo Chen, Hanwen Zhang, Yuelin Wu   +5 more
doaj   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Performance study of a mixed-flow impeller by means of partial impellers.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B, 1986
A mixed-flow impeller with a specific speed of 750 (m3/min, m, rpm) was chosen as a prototype. Quasi three-dimensional potential flow analysis was conducted on the impeller, and three partial impellers having casing geometries equal to 3/4, 2/4 and 1/4 flow-rate meridional stream lines of the prototype impeller were further introduced.
ENOMOTO, Hisao, KAWADA, tatsuo, OHASHI, Hideo, MATSUMOTO, Yoichiro, TANAKA, Kazuhiro   +4 more
openaire   +2 more sources

Comparative Analysis of Bioreactor Design and Scale‐Up for Cultivated Meat Using Monte Carlo‐Based Timescale Modeling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens, Marcel Ottens, Cees Haringa   +2 more
wiley   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source