Results 51 to 60 of about 31,845,692 (279)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Performance Assessment for Cognitive Cooperative Multiple Relays Network (CCMRN) With Imperfect Channel State Information

IEEE Access, 2018
In the underlay spectrum sharing approach, cognitive radios have limited coverage area to keep interference protection for the licensed users. Multiple cooperative relays have shown benefit for allowing reliable communication with an increase in the ...
Wafaa Radi, Reem H. Abdel-Hadi, Hesham M. El-Badawy, Salwa H. El-Ramly   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Improved LAS Detector for MIMO Systems with Imperfect Channel State Information [PDF]

2018 IEEE 29th Annual International Symposium on Personal, Indoor and Mobile Radio Communications (PIMRC), 2018
Likelihood ascent search (LAS) detector is a neighbourhood search algorithm and one of the simplest schemes for low‐complexity near‐optimal detection in massive multiple‐input multiple‐output systems. LAS detector design under the assumption of perfect channel state information has been an area of research for decades.
Issa Chihaoui, Mohamed Lassaad Ammari, Paul Fortier   +2 more
openaire   +2 more sources

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

On the Energy Efficiency of Interference Alignment in the $K$ -User Interference Channel

IEEE Access, 2019
Interference alignment (IA) is regarded as an important physical-layer interference management technique. Most research contributions on IA were focused on the analysis of its achievable spectral efficiency, either from the degrees of freedom or from the
Xiaqing Miao, Shaoshi Yang, Changhong Wang, Shuai Wang, Lajos Hanzo   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Joint Channel Prediction Aided Differentially Encoded TTCM and BICMID Assisted Eigen-Beamforming

, 2007
Eigen-beamforming is capable of providing attractive performance gains in the context of multiple-input multiple-output systems, provided accurate channel state information (CSI) is available.
Liu, W., Ng, S. X., Yang, L-L., Hanzo, L.   +3 more
core   +1 more source