Results 111 to 120 of about 1,597,070 (284)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Genetic and memetic algorithms for scheduling railway maintenance activities [PDF]

Nowadays railway companies are confronted with high infrastructure maintenance costs. Therefore good strategies are needed to carry out these maintenance activities in a most cost effective way.
Dekker, R., Kaymak, U., Budai-Balke, G.
core  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Periodical Maintenance Modelling and Optimisation Assuming Imperfect Preventive Maintenance and Perfect Corrective Maintenance

, 2021
I denna rapport modelleras en periodisk underhållsmodell baserat på antagandenakontinuerlig tillsyn,. ofullständigt förebyggande underhåll (FU) och perfektavhjälpande underhåll (AU) genom tre beslutsvariabler (I, N, Z). Modellen härledsinom ramen för en oändlig planeringshorisont där genomsnittskostnaden pertidsenhet modelleras.
Engvall Birr, Madeleine, Lansryd, Lisette   +1 more
openaire   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Machining Center Opportunistic Maintenance Strategy Using Improved Average Rank Method for Subsystem Reliability Modeling

Applied Sciences
Machining centers are complex systems that consist of multiple subsystems. When maintaining these subsystems, considering opportunistic maintenance can prevent frequent shutdowns during the machining process and reduce costs.
Yingzhi Zhang, Minqiao Song, Wei Wu, Feng Han   +3 more
doaj   +1 more source

Maintenance policy optimisation for multi-component systems considering degradation of components and imperfect maintenance actions

, 2018
International audienceThis article proposes a stochastic optimisation model in order to reduce the long-term total maintenance cost of complex systems. The proposed work is based on the following approaches: (i) optimisation of a cost model for complex ...
Rezg, Nidhal, Castaneda, Leonel,, Castaneda, Leonel, F, Bistorin, Olivier, Martinod, Ronald   +4 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source