Results 211 to 220 of about 74,497 (338)

Considerations for drug trials in hypertrophic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant   +17 more
wiley   +1 more source

Ambivalence in the Context of Competing Narratives: Exploration Through a Case of the US Military Base Issue in Okinawa

open access: yesEuropean Journal of Social Psychology, EarlyView.
ABSTRACT The current research focused on how competing narratives (i.e., dominant and resistance narratives) are endorsed among low‐status group members, through the case of the US military base issue in Okinawa, Japan. Specifically, we explored patterns of Okinawans’ narrative endorsement (i.e., dominant and resistance narratives surrounding the ...
Maho Aikawa, Andrew L. Stewart
wiley   +1 more source

Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis: A shared phenotype across brain‐expressed sodium channelopathies

open access: yesEpilepsia, EarlyView.
Abstract Objective Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain‐of‐function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A‐, SCN3A‐, and SCN8A‐related developmental and ...
Sopio Gverdtsiteli   +43 more
wiley   +1 more source

Sensitivity of Risk‐Based Demand Curves to Analytical Fragility Function Fitting Using Multiple‐Stripe Analyses

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Risk‐based seismic assessments using demand curves that provide mean annual exceedance rates for various system demand levels are increasingly being adopted. Such assessments combine the seismic hazard curve with fragility functions for each demand level, serving as a basis to quantify the average annual losses from system damage. Constructing
Zeyad Khalil   +2 more
wiley   +1 more source

Evaluation of the Adequacy of Design Specifications for Nonstructural Components in a Reticular Structure

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Nonstructural components (NSCs) installed in large‐span reticular structures were frequently severely damaged during earthquakes, even when the primary structure remained intact. Existing seismic design specifications for NSCs were predominantly developed for upright structures such as multi‐storey buildings and offer no guidance for reticular
Xudong Zhi   +6 more
wiley   +1 more source

An Efficient Quasi‐Static Condensation‐Based Framework for Seismic Analysis of Multi‐Supported Secondary Structures

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Multi‐supported non‐structural components (NSCs) are prone to seismic damage, yet their response prediction remains challenging when support motions are spatially incoherent. This study proposes an enhanced quasi‐static condensation (EQSC) method for linear, lightweight, dynamically detuned multi‐supported NSCs under the neglect of primary ...
Duozhi Wang   +5 more
wiley   +1 more source

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