Results 181 to 190 of about 892 (250)

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Production of Prophylactic Nanoformulation for Dental Caries and Investigation of Its Effectiveness by In Vitro and In Silico Methods. [PDF]

Pharmaceutics
Budama-Kilinc Y, Kurtur OB, Gok B, Kecel-Gunduz S, Alpay-Karaoglu S, Yılmaz Atalı P, Kartal M.   +6 more
europepmc   +1 more source

New onset refractory status epilepticus (NORSE) versus refractory status epilepticus not meeting NORSE criteria: A comparative clinical and electroencephalography‐based study

Epilepsia, EarlyView.
Abstract Objective New onset refractory status epilepticus (NORSE) is a rare, severe presentation of refractory status epilepticus (RSE), with approximately half of cases cryptogenic NORSE (c‐NORSE). We compared electroencephalographic (EEG) findings alongside clinical features between NORSE and RSE not meeting NORSE criteria to better understand ...
Seren Hawksworth, Nina Moutonnet, Gregory Scott, Sanjeev Rajakulendran, Mahinda Yogarajah, Matthew C. Walker, Umesh Vivekananda   +6 more
wiley   +1 more source

Structural morphometry distinguishes vagus nerve stimulation outcomes in individuals with epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Vagus nerve stimulation (VNS) is a commonly used treatment for drug‐resistant epilepsy. However, response to VNS is variable, while understanding of this response variability is limited. The vagus afferent network (VagAN), the neural circuits thought to be involved in response to vagal afferents, has been implicated in response ...
Harry J. Clifford, Sonja Fenske, Yujiang Wang, Tiago da Silva Costa, Rhys H. Thomas, Sabahat Iqbal, Cameron A. Elliott, Davide Giampiccolo, John S. Duncan, Peter N. Taylor   +9 more
wiley   +1 more source

Learning Rocking Dynamics From Sparse Shake‐Table Data With Interpretable Physics‐Informed Neural Networks

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT We present a hybrid interpretable Physics‐Informed Neural Network Long‐Short Term Memory (Hybrid PINN LSTM) framework for predicting the seismic response of rocking blocks. Existing analytical models rely on uncertain idealizations, while purely data‐driven and machine‐learning approaches lack physical consistency and interpretability.
Shirley Shen, Christian Málaga‐Chuquitaype   +1 more
wiley   +1 more source

Protein structures unravel the signatures and patterns of deep time evolution. [PDF]

QRB Discov
Harish A.
europepmc   +1 more source

Rocking and Rolling of Rigid Polygons Under Seismic Excitation

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT We present an event driven analytical framework for rigid cyclic polygons subjected to horizontal ground excitation in which uplift, impact, and successive pivot switching are treated within a unified non‐smooth dynamical description. Rolling is defined as a sequence of energetically admissible transitions between neighbouring vertices tied to
Atif Rasheed, Christian Málaga‐Chuquitaype   +1 more
wiley   +1 more source

Significance of an Early Repeat Troponin Measurement Upon Presentation to the Hospital for Acute Heart Failure. [PDF]

J Am Heart Assoc
Horiuchi Y, Maisel AS, van Veldhuisen DJ, Mueller C, Hogan C, Kontos MC, Cannon CM, Müller GA, Müller GA, Taub P, Vilke GM, Duff S, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Murray PT, Wettersten N.   +18 more
europepmc   +1 more source

Climate Driven Water Table Changes and Their Influence on Liquefaction Response of Integral Bridges

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Integral abutment bridges (IABs) eliminate bearings and joints but transfer seismic demand directly into the surrounding soil, making their response highly sensitive to groundwater conditions and soil–structure interaction. This study presents a 60 g centrifuge testing programme on single‐span IABs designed to isolate the influence of water ...
Yazan B. Asia, Gopal S. P. Madabhushi
wiley   +1 more source

Calorie‐Free Menus as a Potential Mitigation Strategy for Mandatory Calorie Labelling: Evidence From People With Disordered Eating in England

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Since the introduction of mandatory out‐of‐home calorie labelling in England, concerns have been raised about potential negative impacts on people with disordered eating. To mitigate these concerns, food outlets can provide calorie‐free menus on request.
Nora Trompeter, Abinaya Nadarajah, Fiona Duffy, Helen Sharpe, Ellen Maloney, Ulrike Schmidt, Lucy Serpell, Dasha Nicholls, Tom Jewell   +8 more
wiley   +1 more source