Results 161 to 170 of about 631,333 (340)
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy+14 more
wiley +1 more source
RECIPROCAL RELATION BETWEEN THE HYPOPHYSIS AND ADRENALS IN FETAL RATS: EFFECTS OF UNILATERAL ADRENALECTOMY AND OF IMPLANTED CORTISONE, DOCA AND SEX HORMONES123 [PDF]
Ralph L. Kitchell, L. J. Wells
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This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi+2 more
wiley +1 more source
Zur Frage über die Implantation von Embryonalgewebe [PDF]
Baron M. Tiesenhausen
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We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang+7 more
wiley +1 more source
THE EFFECT OF PREGNANCY ON IMPLANTED EMBRYONIC TISSUE [PDF]
Peyton Rous
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Mapping Hsp104 interactions using cross‐linking mass spectrometry
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal+3 more
wiley +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls+9 more
wiley +1 more source
REACTIONS OF THYROID GLANDS TO JUXTATHYROIDAL IMPLANTS OF THYROTROPIC AGENTS1 [PDF]
Aubrey Gorbman
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