Results 121 to 130 of about 407,817 (263)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Increased bone formation to unstable nano rough implants
, 2007 Early bone response to cylindrical smooth titanium implants (S(a)=0.1 microm) inserted into the rabbit tibia was compared in a stable and nonstable regime.
Arvidsson, Anna, +3 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Immunohistochemistry of soft tissues surrounding late failures of Brånemark implants
, 1997 The objective of the present investigation was to characterize the cellular composition of the soft tissues surrounding consecutively retrieved late failures of Brånemark implants.
Esposito, Marco, +5 more
core
Sol-gel derived hydroxyapatite, fluorhydroxyapatite and fluorapatite coatings for titanium implants [PDF]
, 2009 Currently, most titanium implant coatings are made using hydroxyapatite and a plasma-spraying technique. There are however limitations associated with the plasma-spraying process including; poor adherence, high porosity and cost.
Tredwin, C.J.
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Plasminogen activator in human gingival tissue adjacent to dental implants.
, 1992 The installment of endosseous dental implants has become an accepted treatment procedure, and the long-term clinical results appear excellent. The composition of the soft tissue environment, however, is different from that around natural teeth.
Schmid, J +7 more
core +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Development of a Self-assembly Technique for Drug-Delivering Hydroxyapatite Coatings for Ti-Based Implants [PDF]
, 2010 PhD 2010 QMTo facilitate the long term osteointegration of Ti implants of various forms, methods aiming to facilitate hydroxyapatite deposition and enhance its adhesion to the Ti surfaces have to be developed.
Ajami, Elnaz
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source