Results 91 to 100 of about 4,765,367 (286)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Making Sense of it All : Conducting KSTE with Canadian Public Health
, 2007 National Collaborating Centre for Determinants of Health. (2007). A report on the NCC’s 2nd annual summer institute: Making sense of it all: Conducting KSTE with Canadian public health. Antigonish, NS: Author. ISBN 978-1-926823-04-
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
BACKGROUND: Despite the critical need for comprehensive and effective chronic pain care, delivery of such care remains challenging. Group medical visits (GMVs) offer an innovative and efficient model for providing comprehensive care for patients with ...
Brintz, Carrie +8 more
core +1 more source
Theories, models, and frameworks in implementation science : a taxonamy
, 2022 This essay presents a taxonomy that distinguishes among different categories of theories, models, and frameworks used in implementation science. The essay describes five categories of theoretical approaches that achieve three overarching aims: 1) process
Nilsen, Per,
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Implementation Science CommunicationsBackground Greater understanding of how evidence-based programs have been implemented in clinical practice and community settings is needed. Implementation science can help understand how to best implement programs, however, the fast-developing field is ...
Tineke E. Dineen +5 more
doaj +1 more source
Making sense of implementation theories, models and frameworks [PDF]
, 2015 Background: Implementation science has progressed towards increased use of theoretical approaches to provide better understanding and explanation of how and why implementation succeeds or fails.
Nilsen, Per, Nilsen, Per,, Per Nilsen
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The Influence of Socio-economic Status and Ethno-racial Status on the Health of Young Children
, 2008 National Collaborating Centre for Determinants of Health. (2008). The influence of socio-economic status and ethno-racial status on the health of young children and their families.
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