Results 131 to 140 of about 4,765,367 (286)

Tailoring the CFIR to Medication Adherence Interventions: A Delphi and Living Lab Study

Pharmacy
The implementation of medication adherence interventions is suboptimal. To guide implementation, this study aimed to tailor an existing implementation determinant framework to support the assessment of the implementability of such interventions in a ...
Mirthe A. M. Oude Lansink, Bart J. F. van den Bemt, Caroline H. P. A. van de Steeg-van Gompel, Marcia Vervloet, Liset van Dijk, Charlotte L. Bekker   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Optimizing implementation: elucidating the role of behavior change techniques and corresponding strategies on determinants and implementation performance: a cross-sectional study

Implementation Science Communications
Introduction Behavior change techniques (BCTs) are considered as active components of implementation strategies, influencing determinants and, ultimately, implementation performance.
Eveline M. Dubbeldeman, Mathilde R. Crone, Jessica Christina Kiefte-de Jong, Rianne M.J.J. van der Kleij   +3 more
doaj   +1 more source

Theories, models and frameworks for de-implementation of low-value care : A scoping review of the literature

, 2020
Achieving an evidence-based practice not only depends on implementation of evidence-based interventions (programs, methods, etc.) but also requires de-implementing interventions that are not evidence-based, that is, low-value care (LVC).
Ingvarsson, S.,, Nilsen, P.,, Hasson, H.,, Augustsson, H.,, von Thiele Schwarz, Ulrica,   +4 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Tools and Approaches for Assessing and Supporting Public Health Action on the Social Determinants of Health and Health Equity

, 2012
National Collaborating Centre for Determinants of Health (NCCDH) & National Collaborating Centre for Healthy Public Policy (NCCHPP). (2012). Tools and approaches for assessing and supporting public health action on the social determinants of health ...
Ndumbe-Eyoh, Sume, Mendell, Anika, Morrison, Val, Dyck, Lesley   +3 more
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Lion Hearts: applying implementation mapping to plan the delivery of a family-based physical activity intervention in community CrossFit affiliates

Frontiers in Public Health
BackgroundCommunity-based physical activity interventions face challenges in adoption, implementation, and sustainability. Lion Hearts is a family-based physical activity intervention designed to promote cardiovascular health among mothers and children ...
Janette Watkins, Janelle Goss, Kelton Mehls, Ali Marshall, Deirdre Dlugonski, Danielle Symons Downs, Danielle Symons Downs   +6 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Inter-related mechanisms of engagement in adaptive yoga for acquired brain injury: a qualitative implementation mapping study

Frontiers in Health Services
BackgroundAcquired brain injury (ABI) is associated with chronic physical, cognitive, emotional, and social impairments requiring long-term rehabilitation.
Jennifer A. Weaver, Jennifer A. Weaver, Jessica Bombino-Elliott, Janell Pisegna, Alec M. Grove, Jaclyn A. Stephens, Arlene A. Schmid   +6 more
doaj   +1 more source