Results 131 to 140 of about 4,836,532 (286)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

MANAGEMENT PERSONNEL LEADERSHIP POTENTIAL OF HIGHER EDUCATION INSTITUTIONS DEVELOPMENT

Університети і лідерство, 2015
The article consists of theoretical analysis of the concept of «leadership potential» in connection to the concepts of «leadership» and «personal potential»; the components of the leadership potential are defined.
Nelia Lebid
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Ambidextrous leadership and innovation: a process perspective and an experimental approach

Humanities & Social Sciences Communications
Ambidextrous leadership is a context-based combination of opening and closing leadership behaviors, and is thought to enhance both leader and employee behaviors in complex innovation processes.
Yiheng Xi, Li Zhou, Haiyan Wang
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Effects of strategic leadership, organizational innovativeness and information technology capability on effective strategy implementation [PDF]

, 2016
The paper examined the role of strategic leadership, organizational innovativeness, information technology capability on strategy implementation in tertiary institutions situated at Kaduna state, Nigeria.
Palladan, Ahmad Aliyu, Abdul Kadir, Kadzrina, Yen, Wan Chong   +2 more
core   +1 more source

Implementing systems- and organisational-level change to advance gender equality in healthcare leadership: a mixed-methods implementation protocol

Implementation Science Communications
Background Despite comprising over 70% of the global healthcare workforce, women remain significantly underrepresented in healthcare leadership. This imbalance has implications for care quality, as leadership diversity is increasingly recognised as a ...
Belinda Garth, Anusha Ramani-Chander, Jenny Proimos, Darren Rajit, Erwin Loh, Elizabeth Sigston, Graeme Currie, Kathleen Riach, Mariam Mousa, Helena Teede, on behalf of the Advancing Women in Healthcare Leadership investigator group   +10 more
doaj   +1 more source

How is leadership behavior associated with organization-related variables? Translation and psychometric evaluation of the implementation leadership scale in German primary healthcare. [PDF]

BMC Health Serv Res, 2022
Söling S, Pfaff H, Karbach U, Ansmann L, Köberlein-Neu J, AdAM-Study Group.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source