Results 51 to 60 of about 203,093 (292)

Refining a College Student-Led Implementation Strategy Using Implementation Mapping in a Rural School

Health Behavior Research
Many physical activity (PA) interventions have been designed, yet few are scaled up or sustained. Additional refinement of implementation strategies may improve adoption, implementation, and maintenance of PA interventions.
McKenna G. Major, Julianna F. King, Skyler T. Taaffe , Luke E. Troyer, Zack Waggoner, Derek W. Craig, Richard J. Holden, Vanessa M. Martinez Kercher, Kyle A. Kercher   +8 more
doaj   +1 more source

Specifying and comparing implementation strategies across seven large implementation interventions: a practical application of theory

Implementation Science, 2019
Background The use of implementation strategies is an active and purposive approach to translate research findings into routine clinical care. The Expert Recommendations for Implementing Change (ERIC) identified and defined discrete implementation ...
Cynthia K. Perry, Laura J. Damschroder, Jennifer R. Hemler, Tanisha T. Woodson, Sarah S. Ono, Deborah J. Cohen   +5 more
doaj   +1 more source

Applying implementation frameworks to the clinical trial context

Implementation Science Communications, 2022
Background Clinical trials advance science, benefit society, and provide optimal care to individuals with some conditions, such as cancer. However, clinical trials often fail to reach their endpoints, and low participant enrollment remains a critical ...
Kristian D. Stensland, Anne E. Sales, Laura J. Damschroder, Ted A. Skolarus   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Recommended implementation of electrical resistance tomography for conductivity mapping of metallic nanowire networks using voltage excitation [PDF]

, 2021
Alessandro Cultrera, Gianluca Milano, Natascia De Leo, Carlo Ricciardi, Luca Boarino, Luca Callegaro   +5 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Implementing Evidence-Based Task Strengthening Strategies for Hypertension Control within Ghana’s Community-Based Health Planning Services: A Concept Mapping Analysis [PDF]

, 2021
Solomon Nyame, Juliet Iwelunmor, Kwaku Poku Asante, Joyce Gyamfi, Kwame Adjei, Kingsley Apusiga, Deborah Onakomaiya, Kezia Gladys Amaning Adjei, Angela Aifah, Jacob Plange‐Rhule, Gbenga Ogedegbe   +10 more
openalex   +1 more source