Results 61 to 70 of about 203,093 (292)

Maps for Planning and New Services to Open New Marketing and Working the Road

Journal of Sustainable Construction Materials and Technologies, 2019
This study has been examined what can be done to achieve the best in the state road planning process. It needs to be improved an existing highway. And the result should be predicted and applied.
Mehmet Fatih Altan
doaj   +1 more source

Visualizing implementation: contextual and organizational support mapping of stakeholders (COSMOS)

Implementation Science Communications, 2020
Background While stakeholder mapping is common in public policy, social sciences, and business management, this tool has not often been used in healthcare settings. We developed a new method of healthcare stakeholder mapping, which we call Contextual and
Steven L. Bernstein, June Weiss, Leslie Curry   +2 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Development of a theory-driven implementation strategy for cancer management guidelines in sub-Saharan Africa

Implementation Science Communications, 2020
Background Despite recent international efforts to develop resource-stratified clinical practice guidelines for cancer, there has been little research to evaluate the best strategies for dissemination and implementation in low- and middle-income ...
Rebecca J. DeBoer, Jerry Ndumbalo, Stephen Meena, Mamsau T. Ngoma, Nanzoke Mvungi, Sadiq Siu, Msiba Selekwa, Sarah K. Nyagabona, Rohan Luhar, Geoffrey Buckle, Tracy Kuo Lin, Lindsay Breithaupt, Stephanie Kennell-Heiling, Beatrice Mushi, Godfrey Sama Philipo, Elia J. Mmbaga, Julius Mwaiselage, Katherine Van Loon   +17 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Innovation to impact in spatial epidemiology

BMC Medicine, 2018
Spatial epidemiology is a rapidly advancing field, pushing our abilities to measure, monitor and map pathogens at increasingly finer spatiotemporal scales.
Andrew J. Tatem
doaj   +1 more source

Comparing a standard and tailored approach to scaling up an evidence-based intervention for antiretroviral therapy for people who inject drugs in Vietnam: study protocol for a cluster randomized hybrid type III trial

Implementation Science, 2020
Background People who inject drugs (PWID) bear a disproportionate burden of HIV infection and experience poor outcomes. A randomized trial demonstrated the efficacy of an integrated System Navigation and Psychosocial Counseling (SNaP) intervention in ...
Minh X. B. Nguyen, Anh V. Chu, Byron J. Powell, Ha V. Tran, Long H. Nguyen, An T. M. Dao, Manh D. Pham, Son H. Vo, Ngoc H. Bui, David W. Dowdy, Carl A. Latkin, Kathryn E. Lancaster, Brian W. Pence, Teerada Sripaipan, Irving Hoffman, William C. Miller, Vivian F. Go   +16 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Displacement analysis of the October 30, 2020 (Mw = 6.9), Samos (Aegean Sea) earthquake

Journal of Geodetic Science
Destructive earthquakes with high deformations have occurred in the Aegean region since the historical period. The most destructive of these earthquakes in recent years is the October 30, 2020 (M w = 6.9) Samos (Aegean Sea) earthquake ...
Çırmık A., Ankaya Pamukçu O., Doğru F., Cingöz A., Özdağ Ö. C., Sözbilir H.   +5 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source