Results 241 to 250 of about 7,716,939 (299)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Implementation outcomes included in NIDA Clinical Trials Network (CTN) studies: A systematic review of studies conducted over 20 years. [PDF]

J Subst Use Addict Treat
Gonzalez ST, Horigian VE, Cheng H, Hagedorn HJ, Shmueli-Blumberg D, Campbell CI, Lin C, Rogers E, Baloh J, Hilton R, Vena A, McNeely J, Glass JE.   +12 more
europepmc   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Assessing implementation outcomes from studies addressing medication adherence for hypertension management in Sub-Saharan Africa: a systematic review. [PDF]

BMC Public Health
Egekeze CO, Chukwu C, Vieira D, Gyamfi J, Allegrante JP.   +4 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Integrating Implementation Outcomes into Effectiveness Studies: A Practical Guide for Clinical Interventionists. [PDF]

J Gen Intern Med
Wesolowicz DM, Becker WC, Alegria M, Chin-Purcell L, Glass JE, Knudsen HK, Dow PM, Seal KH, McGinty EB.   +8 more
europepmc   +1 more source

Implementation outcomes of a symptom management intervention in ambulatory oncology practices evaluated using a cluster randomized stepped-wedge trial design. [PDF]

Implement Sci
Smith JD, Bedjeti K, Lancki N, Sloss EA, Merle JL, Kircher S, Coughlin A, Metzger S, Webster KA, O'Connor M, Cahue S, Flores AM, Mai Q, Yanez B, Bass M, Jensen RE, Smith AW, Carroll AJ, Barnard C, George CM, Tsarwhas DG, Richardson K, Penedo FJ, Hemming K, Garcia SF, Scholtens DM, Cella D.   +26 more
europepmc   +1 more source

Re-conceptualizing implementation outcomes of health innovations as modes or attributes: an integrated framework. [PDF]

Front Health Serv
Balayah Z, Stavropoulou C, Scarbrough H, Nigam A, Ziemann A.   +4 more
europepmc   +1 more source

Implementation outcomes from the Hypertension Treatment in Nigeria program: results from a type 2 hybrid interrupted time series trial. [PDF]

Implement Sci
Ye J, Hirschhorn LR, Baldridge AS, Jamro EL, Orji IA, Shedul GL, Ripiye NR, Ojo TM, Eze H, Shedul GJ, Ugwuneji EN, Okoli RCB, Ale BM, Osagie S, Sanuade OA, Iyer G, Kandula NR, Ojji DB, Huffman MD.   +18 more
europepmc   +1 more source

Implementation Outcomes and Their Determinants for Hospital-Led Care Coordination Interventions Targeting Patients With Complex Care Needs: A Qualitative Systematic Review. [PDF]

J Clin Nurs
Malakellis M, Wong Shee A, Wood S, Alston L, Beks H, Murray M, Versace VL, Mc Namara K.   +7 more
europepmc   +1 more source