Results 71 to 80 of about 915,009 (215)

Sustainability through funding and leadership: a mixed-methods study of tobacco treatment programs across U.S. National Cancer Institute-designated Cancer Centers

Implementation Science Communications
Background Tobacco cessation markedly improves cancer treatment outcomes. As part of the National Cancer Institute (NCI) Cancer Moonshot, the Cancer Center Cessation Initiative (C3I) funded 52 U.S.
Miranda J. Reid, Magda K. Montague, Sofia Anrecio, Jennifer H. LeLaurin, Carma L. Bylund, Mara M. Minion, Gonghao Liu, Ji-Hyun Lee, Edmond Ramly, Donna Shelley, Jamie S. Ostroff, Graham Warren, Ramzi G. Salloum   +12 more
doaj   +1 more source

How the experiences of implementation support recipients contribute to implementation outcomes

Frontiers in Health Services
IntroductionThere is a growing body of literature on the activities and competencies of implementation support practitioners (ISPs) and the outcomes of engaging ISPs to support implementation efforts.
Allison J. Metz, Todd M. Jensen, Jenny L. Afkinich, Mackensie E. Disbennett, Amanda B. Farley   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Assessing the health outcomes, productivity gains, and budget impact of anti-PD-(L)1’s in the early stages of cancer treatment in Greece

Frontiers in Oncology
ObjectivesCancer incidence and mortality have been increasing both globally and in Greece. The aim of this study was to quantify the health benefits and budget impact of including anti-PD-(L)1’s in three early-stage cancer indications, adjuvant melanoma ...
Nikolaos Themistoklis Yfantopoulos, Panagiota Naoum, Anastasios Skroumpelos, Antonis Karokis, Demet Sönmez, Raquel Aguiar-Ibañez, Vivek Khurana, Anastasios Boutis, Michail Liontos, Zacharenia Saridaki, Kostas Athanasakis   +10 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Understanding implementation research

African Journal of Primary Health Care & Family Medicine
Implementation research (IR) focuses on understanding and closing the gap between evidence-based interventions and practice. Key elements to evaluate include the design of the intervention itself, contextual barriers and enablers to implementation, the ...
Robert Mash, Juliet Nyasulu, Zelra Malan, Lisa Hirschhorn   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Tailored Multifaceted Strategy for Implementing Fundamental Evidence-Based Nursing Care: An Evaluation Study

Nursing Reports
Background/Objectives: Extensive research has emphasised the persistent challenges and failures in providing hospitalised patients with fundamental evidence-based nursing care, often resulting in grave consequences for patient safety.
Signe Eekholm, Karin Samuelson, Gerd Ahlström, Tove Lindhardt   +3 more
doaj   +1 more source