Results 121 to 130 of about 669,720 (312)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Factors influencing informal carers' acceptance of assistive telecare systems in the pre- and post-implementation phase: A scoping study. [PDF]

Health Soc Care Community, 2022
Hvalič-Touzery S, Dolničar V, Prevodnik K.   +2 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Design & Implementation of High Switching & Low Phase Noise Frequency Synthesizer

Al-Khawarizmi Engineering Journal, 2006
This research describes the design & implementation of frequency synthesizer using single loop Phase lock loop with the following specifications: Frequency range (1.5 – 2.75) GHz,Step size (1 MHz), Switching time 36.4 µs, & phase noise @10 kHz = -92dBc &
Ali M. N. Hassan
doaj  

AI Methods for Implementation Science (AIM-IS): developing a framework, toolkit, and reporting standard for the responsible use of AI in implementation practice and research

Implementation Science
Background Artificial intelligence (AI), including machine learning, natural language processing, and large language models, may support implementation practice and research in tasks such as evidence synthesis, determinant assessment, strategy selection,
Guillaume Fontaine, Susan Michie, Rinad S. Beidas, Elvin Geng, Christine Fahim, Byron J. Powell, Vivian Welch, James Thomas, Jeffery Chan, Samira Abbasgholizadeh-Rahimi, France Légaré, Janna Hastings, Sylvie D. Lambert, Justin Presseau, Sharon E. Straus, Ruopeng An, Ashrita Saran, Natalie Taylor   +17 more
doaj   +1 more source

Developing feasible and acceptable strategies for integrating the use of patient-reported outcome measures (PROMs) in gender-affirming care: An implementation study.

PLoS ONE
ObjectiveUse CFIR guidance to create comprehensive, evidence-based, feasible, and acceptable gender-affirming care PROM implementation strategies.Design, setting, participantsA 3-Phase participatory process was followed to design feasible and acceptable ...
Rakhshan Kamran, Liam Jackman, Anna Laws, Melissa Stepney, Conrad Harrison, Abhilash Jain, Jeremy Rodrigues   +6 more
doaj   +1 more source

Implementation of the Wolverine Mental Health Program, Part 2: Implementation Phase. [PDF]

Cogn Behav Pract, 2022
Rodriguez-Quintana N, Lewis CC, Scott K, Marriot B, Wahlen S, Hindman R.   +5 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Healthcare providers' readiness for electronic health record adoption: a cross-sectional study during pre-implementation phase. [PDF]

BMC Health Serv Res, 2022
Ngusie HS, Kassie SY, Chereka AA, Enyew EB.   +3 more
europepmc   +1 more source