Results 101 to 110 of about 4,069,434 (300)

Health system performance on greenhouse gas emissions, climate change and development status in 38 OECD countries

Scientific Reports
Health systems must solve two climate-related problems simultaneously: mitigate their greenhouse gas emissions and adapt to additional patient loads associated with climate-induced demands for care from weather sequalae and vector-borne diseases.
Jeffrey Braithwaite, Yvonne Tran, Georgia Fisher, Louise A Ellis, Carolynn L Smith, Yvonne Zurynski   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Is implementation science a science? Not yet

Frontiers in Public Health
Getting the science right for implementation is critical for making the processes for improving outcomes more predictable and effective in global public health. Unfortunately, “implementation science” has become a catchphrase for ideas, assumptions, and findings concerning the science to service gap and how to close it.
Dean L. Fixsen, Melissa K. Van Dyke, Karen A. Blase   +2 more
openaire   +3 more sources

Methodology Issues in Implementation Science

Medical Care, 2013
Putting evidence into practice at the point of care delivery requires an understanding of implementation strategies that work, in what context and how.To identify methodological issues in implementation science using 4 studies as cases and make recommendations for further methods development.Four cases are presented and methodological issues identified.
Newhouse, Robin, Bobay, Kathleen, Dykes, Patricia C., Stevens, Kathleen R., Titler, Marita   +4 more
openaire   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Applying Science Models for Search [PDF]

, 2011
The paper proposes three different kinds of science models as value-added services that are integrated in the retrieval process to enhance retrieval quality.
Mayr, Philipp, Mutschke, Peter, Petras, Vivien, Schaer, Philipp, Sure, York   +4 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Importance of Teacher Self-efficacy in the Implementation of a Middle and High School Science Writing Initiative [PDF]

, 2019
This study focuses on the experiences of two science teachers who worked to implement a writing-focused, science literacy project in their classrooms. More specifically, I uncover the ways these teachers’ experiences differed and how these differences ...
Whitacre, Michelle P
core   +1 more source

Implementation science at the crossroads [PDF]

BMJ Quality & Safety, 2017
Martin Marshall and colleagues1 take themselves to task for the suboptimal design of a complex (multicomponent) intervention to improve safety of services for people in care homes. The authors make much of the complexity of the intervention—service interventions are ‘not like a pill’.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source