Results 181 to 190 of about 10,513,270 (364)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Implementation of phase gates using single photons [PDF]

arXiv
Quantum computing algorithms using the quantum Fourier transform require repeated use of a phase shift gate. In the case of qubits using optical photons for operation, this gate can be implemented using single-photon beams focused close to the diffraction limit.
arxiv  

Implementing Strassen's Algorithm with BLIS [PDF]

arXiv, 2016
We dispel with "street wisdom" regarding the practical implementation of Strassen's algorithm for matrix-matrix multiplication (DGEMM). Conventional wisdom: it is only practical for very large matrices. Our implementation is practical for small matrices. Conventional wisdom: the matrices being multiplied should be relatively square.
arxiv  

An Atmospheric Sciences Workflow and Its Implementation with Web Services [PDF]

, 2004
David Abramson, Jagan Kommineni, John L. McGregor, Jack Katzfey   +3 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Integrating training in evidence-based medicine and shared decision-making: a qualitative study of junior doctors and consultants

BMC Medical Education
Background In the past, evidence-based medicine (EBM) and shared decision-making (SDM) have been taught separately in health sciences and medical education.
Mary Simons, Georgia Fisher, Samantha Spanos, Yvonne Zurynski, Andrew Davidson, Marcus Stoodley, Frances Rapport, Louise A. Ellis   +7 more
doaj   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Benefits, implementation and sustainability of innovative paediatric models of care for children with type 1 diabetes: a systematic review

BMC Pediatrics
Background and aim The evidence about the acceptability and effectiveness of innovative paediatric models of care for Type 1 diabetes is limited. To address this gap, we synthesised literature on implemented models of care, model components, outcomes ...
Ann Carrigan, Isabelle Meulenbroeks, Mitchell Sarkies, Genevieve Dammery, Nicole Halim, Nehal Singh, Rebecca Lake, Elizabeth Davis, Timothy W. Jones, Jeffrey Braithwaite, Yvonne Zurynski   +10 more
doaj   +1 more source