Results 191 to 200 of about 675,379 (261)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi   +8 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie   +8 more
wiley   +1 more source

Feasibility and fidelity in applying media advocacy principles as an implementation strategy: lessons from the National ROPS Rebate Program expansion. [PDF]

open access: yesBMC Public Health
Milkovich PJ   +9 more
europepmc   +1 more source

Feasibility of an implementation strategy for preventing falls in homecare services. [PDF]

open access: yesImplement Sci Commun
Linnerud S   +5 more
europepmc   +1 more source

Music as an implementation strategy for evidence-based health interventions in Africa: a systematic review using the RE-AIM framework. [PDF]

open access: yesImplement Sci Commun
Okafor C   +15 more
europepmc   +1 more source

Using implementation mapping to design an implementation strategy for classroom-based physical activity approaches in elementary schools. [PDF]

open access: yesTransl Behav Med
Walker TJ   +9 more
europepmc   +1 more source

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