Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Application of the Main Components Method for GNSS Interference Suppression
In this paper three methods of interferences nulling for GNSS GPS or GLONASS are described. A digital antenna array for compensation of interferences is implied. Two methods are based on the eigenvector decomposition of the correlation matrix of received
A. V. Nemov +2 more
doaj
Causality between stock market and “fear gauge” indices: An empirical analysis with E-statistics
This study investigates empirically the validity of three hypotheses that have been advanced to explain the tendency of stock market and volatility indices to move in opposite directions, using the notion of Brownian distance correlation.
Panos Fousekis, Vasilis Grigoriadis
doaj +1 more source
Fluctuating noise drives Brownian transport
The transport properties of Brownian ratchet was studied in the presence of stochastic intensity noise (SIN) in both overdamped and underdamped regimes.
Kampen V. +5 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Dual Language and ENL Comprehension: A First Grade Study for Students at Risk for Delayed English Language Development [PDF]
This research began by asking how dual language programming impacts English comprehension for ENL students. Research was conducted within one first grade dual language cohort with five bilingual students.
Case, Meghan
core +1 more source
Exponential Decay of Correlations Implies Area Law [PDF]
We prove that a finite correlation length, i.e., exponential decay of correlations, implies an area law for the entanglement entropy of quantum states defined on a line. The entropy bound is exponential in the correlation length of the state, thus reproducing as a particular case Hastings's proof of an area law for groundstates of 1D gapped ...
Brandão, Fernando, Horodecki, Michał
openaire
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Asset Pricing in a General Equilibrium Production Economy with Chew-Dekel Risk Preferences [PDF]
In this paper we provide a thorough characterization of the asset returns implied by a simple general equilibrium production economy with convex investment adjustment costs.
Claudio Campanale +2 more
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source

