Results 221 to 230 of about 89,661 (283)

Waiting List Policy Reform Is Required to Enable Randomised Controlled Trials of Elective Surgery

ANZ Journal of Surgery, EarlyView.
Jonathan G. Quicke, Deborah J. Brown, Bernadette Richards, Owen Ung, Catherine McDougall, Sandra Crone, Nadine E. Foster   +6 more
wiley   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Oral Health‐Related Quality of Life by Age and Gender: A Cross‐Sectional Study of Home‐Dwelling Older Adults

Gerodontology, EarlyView.
ABSTRACT Objectives Oral health‐related quality of life (OHRQoL) reflects the impact of oral health on daily activities. Understanding how OHRQoL varies by age and gender among older adults remains limited and inconsistent. This study aimed to investigate differences in OHRQoL by age and gender among home‐dwelling older adults.
Jessica Friberg, Susanna Nordin, Susanne Lindqvist, Anne Wissendorff Ekdahl, Riccardo LoMartire   +4 more
wiley   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

An enhanced adaptive large neighborhood search algorithm for the multiple allocation p‐hub location problem with a mesh backbone network in video‐on‐demand services

International Transactions in Operational Research, EarlyView.
Abstract This study tackles the multiple allocation p$p$‐hub location problem (MApHLP) in the context of video‐on‐demand services, where digital content is partitioned into segments and stored exclusively at selected hub locations. Users, distributed across a wide geographical area, can connect to multiple hubs based on demand patterns, with all hubs ...
Soumen Atta
wiley   +1 more source

Mapping the Drivers of Engagement in Mentorship in Nursing Clinical Practicums: A Network Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To map factors influencing nurses' engagement in clinical mentorship in nursing education and explore their interactions using network analysis. Design Observational cross‐sectional study employing an online survey from July 2024 to May 2025.
Eva Padrosa, Aggie Núñez‐Doyle, Raquel Ayuso‐Margañon, Rosa Rifà‐Ros, Montse Sanclemente‐Dalmau, Carlota Alcover, Anna Martín‐Arribas, Ariadna Graells‐Sans, Miriam Rodríguez‐Monforte   +8 more
wiley   +1 more source

Alteration of subgingival microbiome in patients with type 2 diabetes induced by diabetes treatment

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Diabetes and periodontal disease, a bacterial infection involving the oral microbiome, have a bidirectional relationship. However, the relationship between poor glycemic control and the oral microbiome remains unclear. The aim of this study was to assess the direct effect of intensive glycemic control on the oral microbiome ...
Moe Inoue, Akito Sakanaka, Naoto Katakami, Hitoshi Nishizawa, Kazuo Omori, Naohiro Taya, Asuka Ishikawa, Shota Mayumi, Hiroki Takeuchi, Atsuo Amano, Toru Takeshita, Eiichiro Fukusaki, Iichiro Shimomura, Masae Kuboniwa   +13 more
wiley   +1 more source