Results 321 to 330 of about 1,757,599 (384)

Ocean economic input-output tables of coastal provinces in China. [PDF]

Sci Data
Liang X, Zheng C, Zheng L, Zhu K, Zhang Z.   +4 more
europepmc   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

PEX1^G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome. [PDF]

J Biol Chem
Sheedy CJ, Chowdhury SP, Ali BA, Miyamoto J, Pang EZ, Bacal J, Tavasoli KU, Richardson CD, Gardner BM.   +8 more
europepmc   +1 more source

Gradient Nanostructures and Machine Learning Synergy for Robust Quantitative Surface‐Enhanced Raman Scattering

Advanced Science, EarlyView.
A novel SERS platform using gradient nanostructures and machine learning is presented. Gradient nanostructures minimize fabrication variability and enhance spectral diversity. The ML model significantly improves quantification precision, robustness and reproducibility, reducing test MSE by 84.8% and increasing R2 by 61.2%, enabling reliable real‐world ...
Xiaoyu Zhao, Yuxia Wang, Yuting Liu, Xinyi Chen, Mingyu Cheng, Yaxin Wang, Jiahong Wen, Renxian Gao, Kun Zhang, Fengyi Zhang, Rufei Cui, Yongjun Zhang, Zengyao Wang, Bin Ai   +13 more
wiley   +1 more source

Chloroplast precursor protein preClpD overaccumulation triggers multilevel reprogramming of gene expression and a heat shock-like response. [PDF]

Nat Commun
Hong ZH, Zhu L, Gao LL, Zhu Z, Su T, Krall L, Wu XN, Bock R, Wu GZ.   +8 more
europepmc   +1 more source

The Molecular Basis of Amino Acids Sensing

Advanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang, Xiao Tan, Jiali Jin, Ping Wang   +3 more
wiley   +1 more source

A Sleep Sensor Made with Electret Condenser Microphones. [PDF]

Clocks Sleep
Kamogashira T, Yamasoba T, Kikuta S, Kondo K.   +3 more
europepmc   +1 more source

Hydrogen‐Producing Catalysts Based on Ferredoxin Scaffolds

Advanced Science, EarlyView.
Selected plant‐type ferredoxins that lack their natural [2Fe‐2S] clusters functionally bind a hydrogenase active site cofactor and act as hydrogenases themselves. In combination with photosystem I, the light‐dependent H₂ evolution almost matches the H₂ production rates of the natural system.
Yiting She, Vera Engelbrecht, Jacek Kozuch, Ulf‐Peter Apfel, Sven T. Stripp, Anja Hemschemeier, Thomas Happe   +6 more
wiley   +1 more source

The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development. [PDF]

PLoS Genet
Strohdiek A, Köhler AM, Harting R, Stupperich H, Gerke J, Bastakis E, Neumann P, Ahmed YL, Ficner R, Braus GH.   +9 more
europepmc   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source