Results 121 to 130 of about 1,563,953 (295)

FINANCIAL AND ORGANIZATIONAL PROBLEMS OF IMPORT SUBSTITUTION IN RUSSIA

open access: yesВестник университета, 2016
Internal and external theoretical and practical problems of import substitution are considered. The analysis of methods and approaches of scientists and authorities to the solution of these problems is stated, some results of financing of process of ...
O. Makhalina
doaj  

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

open access: yesAdvanced Science, EarlyView.
The comprehensive proteomic and N‐glycoproteomic analyses of 45 colorectal cancer tissues with matched normal adjacent tissues identified 7125 intact N‐glycopeptides from 704 glycoproteins. A glycosylation site‐protein function network revealing metabolic dysregulation is constructed and a model differentiating tumors from normal tissues is developed ...
Guobin Liu   +10 more
wiley   +1 more source

Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations

open access: yesAdvanced Science, EarlyView.
This study investigates bidirectional introgression between Chinese and European pig populations, revealing 3558 introgressed genomic segments and 30 structural variations. Analysis of the BMP2 region suggests its role in body size enhancement. By integrating ancient and modern genomes, the study highlights the impact of introgression on genetic ...
Yibin Qiu   +19 more
wiley   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

open access: yesAdvanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li   +21 more
wiley   +1 more source

FINANCIAL AND ORGANIZATIONAL PROBLEMS OF IMPORT SUBSTITUTION IN RUSSIA

open access: yesВестник университета, 2019
Internal and external theoretical and practical problems of import substitution are considered. The analysis of methods and approaches of scientists and authorities to the solution of these problems is stated, some results of financing of process of ...
O. Makhalina
doaj  

Programmable Metamaterials with Perforated Shell Group Supporting Versatile Information Processing

open access: yesAdvanced Science, EarlyView.
This study proposes a novel mechanical metamaterial with high‐density memory based on multi‐stable perforated shells to realize multi‐layer information encoding, storage, decoding, and reading. The metamaterial can perform more application‐oriented tasks to process information, such as encryption and dynamic behavior regulation, which hopefully enables
Xiaoyuan Ma   +3 more
wiley   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

open access: yesAdvanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng   +10 more
wiley   +1 more source

A Nanostructured Ru‐Mn‐Nb Alloy with Oxygen‐Enriched Boundaries for Ampere‐Level Hydrogen Evolution

open access: yesAdvanced Science, EarlyView.
Ru62Mn12Nb21O5 medium‐entropy alloy with a crystal‐crystal dual‐phase structure is deposited on a carbon cloth substrate by the magnetron sputtering method. The oxygen‐rich interface induced by the rich Mn phase and the poor Mn phase optimized the electronic structure of the catalyst, adjusted the adsorption and desorption processes of intermediates ...
Jie Li   +12 more
wiley   +1 more source

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