Results 121 to 130 of about 189,214 (341)

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
wiley   +1 more source

Conceptual Relationships between the Systems of Ensuring the Economic Security of the State and the Implementation of the State Policy of Import Substitution [PDF]

Problemi Ekonomiki, 2017
The aim of the article is to substantiate the conceptual relationships between the systems of ensuring the economic security of the state and the implementation of the state policy of import substitution.
Lupak Ruslan L., Kunytska-Iliash Marta V.   +1 more
doaj  

Innovation Promotion and Learning in International Trade: the Case of Colombian Manufacturing Exports [PDF]

Colombian manufacturing exporting firms survey results are analyzed highlighting innovation, promotion, and learning, as well as the influence of factors such as: size, ownership, output objectives, destination of exports, competition and pricing, export
Simon Teitel
core  

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Import substitution as a factor of stabilization of the Russian budget system

Путеводитель предпринимателя, 2020
The effect of economic and trade sanctions on the development of import substitution and state of the budget system in Russia. Examples of investment projects aimed at implementing the policy of import substitution.
O. N. Dolina
doaj  

ECONOMIC AND FOOD SECURITY: NEW REALITY OF IMPORT SUBSTITUTION [PDF]

Техника и технология пищевых производств, 2016
The article discusses new aspects of the theory and practice of economic and food security when realizing the policy of import substitution in the agro-industrial complex.
Kopein V.V.
doaj  

Policies for promoting technological catching up: towards post-Washington approach [PDF]

, 2007
This paper analyses the evolution of policies for technology catch-up through three periods: import-substitution, (augmented) Washington consensus and post-Washington period. We analyse the dominant policy models and practices in each of these periods as
Radošević, S.
core  

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

FOOD AND ECONOMIC SECURITY OF RUSSIA IN MODERN CONDITIONS [PDF]

Техника и технология пищевых производств, 2015
This article deals with the problem of food security as an element of economic security of Russia in the light of weakening of world economic relations. The necessity to adjust the economic security monitoring systems is grounded.
Kopein V.V., Filimonova E.A.
doaj