Results 151 to 160 of about 873,455 (223)

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Modeling the pattern of structural change in Saudi Arabian import demand (gradual switching regression)

, 1998
The question of stability in import demand in the atea of international trade is of eminent practical importance. In this paper, the hypothesis of structural change in Saudi Arabian import demand is tested in five regions using LNAIDS (Linear ...
AI-Kheraiji, Abdulla A.
core  

Navigating AI with pedagogical purpose: Toward an anatomy‐centered framework for AI‐enhanced learning

Anatomical Sciences Education, EarlyView.
Abstract Artificial Intelligence (AI) has emerged as a transformative force in medical education, enabling customized, feedback‐rich, and immersive learning experiences. Anatomy education, as a discipline that is simultaneously visual, spatial, and clinically foundational, occupies a distinctive position within this technological landscape.
Rachel Jayasekhar, Gok Kandasamy
wiley   +1 more source

Estimating the import demand function in the autoregressive distributed lag framework: The case of China [PDF]

This paper uses the concept of cointegration for empirically analyzing the long-run relationship of China's import demand function. The analysis employs the annual data for the sample period from 1978 to 2009.
Shigeyuki Hamori, Fengbao Yin
core  

Dissecting the dissection laboratory: Elements for designing a human anatomy laboratory

Anatomical Sciences Education, EarlyView.
Abstract The human anatomy dissection laboratory is a critical component of anatomical and medical education. Development, maintenance, and stocking of these laboratory spaces have unique demands, with all of the challenges in running a laboratory with Biosafety Laboratory Level 2 (BSL‐2) classification, housing a large volume of tissues saturated with
Rhiannon E. Robinson, Abbey Breckling, Danielle N. Edwards, Nicole Geske, Burhan Gharaibeh, Bobbie J. Leeper, Molly Ostwald, Mary Schilling, Bridgett Severt, Kelsey Stevens, J. P. Swigart, Jonathan J. Wisco, Melissa Zolnierz, Jeremy J. Grachan   +13 more
wiley   +1 more source

U.S. Citrus Import Demand: Seasonality and Substitution [PDF]

Citrus fruits make up one-fifth of all fresh fruit consumed in the United States. Given the increasing importance of imported citrus in the diet of American consumers, it is perhaps surprising that no import demand analysis of U.S.
Baldwin, Katherine L., Jones, Keithly G.
core  

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Exchange Rate Pass-Through into Import Prices: The Case of Chile [PDF]

In this paper we estimate the exchange rate pass-through (ERPT) into disaggregated import price data at monthly frequency. We work with import prices both at the border and at the wholesale level, and our results are consistent with the idea of a high ...
Roberto Álvarez, Jorge Selaive, Patricio Jaramillo   +2 more
core  

Capacity building in medicines development and regulation in Africa—Overview on recent progress

British Journal of Clinical Pharmacology, EarlyView.
Aims Despite advances in health research and digital innovation, many African countries continue to face substantial resource constraints, fragmented capacity‐building efforts and a shortage of skilled professionals in medicines development and regulatory science.
Tirhani Maluleke, Emile Malan, Michael Reid, Patrick Bouic, Haylene Nell, Goonaseelan Pillai, Catriona Waitt, Bernd Rosenkranz   +7 more
wiley   +1 more source

Beyond salaries: Teachers' experiences of navigating early years education amid economic instability in Türkiye

British Educational Research Journal, EarlyView.
Abstract The intersection of economic conditions and early years education has long been debated, particularly where financial constraints shape educational practice and professional realities. Türkiye, characterised by high inflation and structural vulnerabilities in purchasing power parity, provides a critical context for examining how economic ...
Ebru Aydın, Şerif Yüksel
wiley   +1 more source