Results 81 to 90 of about 1,153,181 (253)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An importance-performance analysis of teachers' perception of STEM engineering design education. [PDF]

Humanit Soc Sci Commun, 2023
Chien YH, Chang FY.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Sustainable transportation: Definitions, dimensions, and indicators - Case study of importance-performance analysis for the city of Tehran. [PDF]

Heliyon, 2023
Heidari I, Eshlaghy AT, Seyyed Hoseini SM.   +2 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Addressing antecedents’ importance of open innovation between industry and universities: A neural network-based importance-performance analysis with a fuzzy approach

Alexandria Engineering Journal
Determining the importance of major antecedents of open innovation between such distinct partners as industry and universities influences the decision-making regarding resources and effort allocation to their improvement, according to the strategic ...
Marius Băban, Călin-Florin Băban
doaj   +1 more source

Importance-performance analysis in fitness apps. A study from the viewpoint of gender and age. [PDF]

Front Public Health, 2023
Martín F, García-Fernández J, Valcarce-Torrente M, Bernal-García A, Gálvez-Ruiz P, Angosto-Sánchez S.   +5 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Evaluation and improvement of workplace vertical violence of nursing interns based on the Importance-Performance Analysis method. [PDF]

Front Med (Lausanne), 2023
Xu W, Feng L, Huang H, Liu S, Ye M, Tang F, Chuang YC, Cai F.   +7 more
europepmc   +1 more source