Results 281 to 290 of about 2,707,715 (327)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Women's preferences for HPV self-sampling in cervical cancer screening: a discrete choice experiment. [PDF]

Front Public Health
Ding N, Chen Y, Zhou X, Wang G, Li J, Wang X.   +5 more
europepmc   +1 more source

Defining an onychomycosis cohort: The importance of mycologic sampling. [PDF]

JAAD Int
Reich D, Lipner SR.
europepmc   +1 more source

Simulation seltener Ereignisse mittels Importance Sampling unter besonderer Berücksichtigung Markovscher Modelle

, 2004
Werner Sandmann
openalex   +1 more source

Response to Reich and Lipner, "Defining an onychomycosis cohort: The importance of mycologic sampling". [PDF]

JAAD Int
Gupta SV, Chen K, Rana J.
europepmc   +1 more source

Identification of Slightly Halophilic Bacteria From Salted Sheepskin Samples and Investigation of Their Biotechnological Importance

Pinar B. Caglayan
openalex   +1 more source

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The importance of importance sampling

Computing in Science & Engineering, 1999
Importance sampling is an underappreciated Monte Carlo technique. The authors have used it with great success. They share their insights. Importance sampling is designed to reduce the variance of the estimators for a given-size sample.
Isabel Beichl, Francis Sullivan
openaire   +1 more source

Precomputed importance sampling

ACM SIGGRAPH 2008 posters, 2008
We present a method for cosine-weighted importance sampling of environment maps. Our technique has no runtime overhead. It is well suited for real-time ray tracing and for algorithms that generate only a few shadow rays per primary ray. Both memory consumption and preprocessing time are very low.
Manfred Ernst, Günther Greiner
openaire   +1 more source