Results 121 to 130 of about 4,591,150 (298)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

The time serial distribution and influencing factors of asymptomatic COVID-19 cases in Hong Kong

One Health, 2020
Jun Tao, Xiaoyu Zhang, Xingyue Zhang, Shi Zhao, Lin Yang, Daihai He, Huaichen Li   +6 more
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Distribution of reported imported dengue cases by sex and age, Japan, 2006–2014 (n = 1007).

, 2016
Distribution of reported imported dengue cases by sex and age, Japan, 2006–2014 (n = 1007).
Kazunori Oishi (331892), Tamano Matsui (846598), Hitomi Kinoshita (3067851), Tomoe Shimada (287362), Tomimasa Sunagawa (247529), Munehisa Fukusumi (3067863), Tomohiko Takasaki (181625), Takeshi Arashiro (3067857), Yuzo Arima (3067854), Ashley Arashiro (3067860)   +9 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Ongoing increase in measles cases following importations, Japan, March 2014: times of challenge and opportunity

Western Pacific Surveillance and Response, 2014
Takuri Takahashi, Yuzo Arima, Hitomi Kinoshita, Kazuhiko Kanou, Takehito Saitoh, Tomimasa Sunagawa, Hiroaki Ito, Atsuhiro Kanayama, Ayako Tabuchi, Kazutoshi Nakashima, Yuichiro Yahata, Takuya Yamagishi, Tamie Sugawara, Yasushi Ohkusa, Tamano Matsui, Satoru Arai, Hiroshi Satoh, Keiko Tanaka-Taya, Katsuhiro Komase, Makoto Takeda, Kazunori Oishi   +20 more
doaj   +1 more source

Case series of Oropouche fever among travellers returning from Cuba to Spain, 2024

Eurosurveillance
Oropouche fever is a vector-borne disease endemic in Central and South America. Infection with Oropouche virus (OROV) was confirmed in June and July 2024 in 13 patients travelling from Cuba to Spain.
on behalf of the Spanish-OROV Study Group
doaj   +1 more source

Weekly distribution of confirmed imported, autochtonous and non classified yellow fever cases, DRC, 2016.

, 2018
Weekly distribution of confirmed imported, autochtonous and non classified yellow fever cases, DRC, 2016.
Harold Noel (6061634), Nadine A. Weregemere (6061631), Benoît I. Kebela (6061649), Axelle Ronsse (6061646), Brecht Ingelbeen (4217443), Gaston P. Tshapenda (6061637), Sandra Cohuet (33744), Mathias Mossoko (6061640), Justus Nsio (6061643), Steve Ahuka-Mundeke (284741)   +9 more
core   +1 more source

Phase Diagrams and Piezoelectric Properties of Wurtzite Al1−x−yScxGdyN Heterostructural Alloys

Advanced Science, EarlyView.
This study demonstrates ferroelectricity and piezoelectric properties improvement of quaternary wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films, guided by density functional theory calculations. Wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films have a high optical bandgap, enhanced piezoelectric ...
Julia L. Martin, Cheng‐Wei Lee, Nate S.P. Bernstein, Thi Nguyen, Ande Bryan, Eli Cooper, John S. Mangum, Sage R. Bauers, Andriy Zakutayev, Keisuke Yazawa, Prashun Gorai, Rebecca W. Smaha   +11 more
wiley   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source