Results 271 to 280 of about 615,527 (345)

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

International trade regulations take a limited bite out of the shark fin trade. [PDF]

Sci Adv
Cardeñosa D, Babcock EA, Shea SK, Zhang H, Feldheim KA, Yang F, Gale SW, Fernando D, Tanna A, Warwick L, D Chapman D.   +10 more
europepmc   +1 more source

The Scope of an owner of imported goods' in view of substance over form principle - Focused on Korean Supreme Court Decision 2014Du8636 decided on November 27, 2014

, 2015
Min Joung Kim, Hun Park
openalex   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

A near-real time daily European Power Consumption and Carbon Intensity Dataset (ECON-PowerCI). [PDF]

Sci Data
Zhang S, Zhao W, Zhu B, Yan C, Song X, Jiang H, Fang J, Ciais P, Xuan N, Gentine P, Davis SJ, Liu Z, Qiu GY.   +12 more
europepmc   +1 more source

Estimating Import-Demand Function in ARDL Framework: The Case of Pakistan [PDF]

, 2010
Abdul Rashid, Tayyaba Razzaq
openalex  

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Genomic surveillance of <i>Salmonella enterica</i> serotype Minnesota strains from poultry products imported into South Africa. [PDF]

Microb Genom
Raghuram V, Mafuna T, Ramnath V, Gourlé H, Blom J, Magwedere K, Carroll LM, Matle I.   +7 more
europepmc   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

The impact of free trade port construction on regional import and export: Evidence from Hainan. [PDF]

PLoS One
Zhao Z, Guan Z, Liu Z, Xie X.
europepmc   +1 more source