Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Inferring Branch-Specific Rates of Lineage Diversification Under the Birth-Death-Shift Process. [PDF]
Syst BiolHöhna S +6 more
europepmc +1 more source
Advanced Science, EarlyView.An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee +11 more
wiley +1 more source
Gender-Attributed Persona Prompts and the Diagnostic Accuracy of Proprietary and Open-Weight Large Language Models in Chagas Disease and Visceral Leishmaniasis: A Paired Experimental Study. [PDF]
Healthcare (Basel)Silva ARSD +14 more
europepmc +1 more source
The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells
Advanced Science, EarlyView.Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato +9 more
wiley +1 more source
Spindle cell hemangioma of the lower abdominal wall mimicking dermatofibrosarcoma protuberans: A case report. [PDF]
JAAD Case RepNagasawa H, Kuwahara H, Ito K, Ogawa R.
europepmc +1 more source
MXene‐Based Room‐Temperature NO2 Gas Sensors: A Meta‐Analysis
Advanced Science, EarlyView.This study presents the first comprehensive meta‐analysis of MXene‐based NO2 sensors, decoding 32 study characteristics across 61 peer‐reviewed studies. By isolating materials chemistry as the primary performance driver over device‐level parameters, the authors establish a methodological blueprint and a predictive structure–function map to accelerate ...
Alexander Khort +3 more
wiley +1 more source
Fed-XLM-R: a privacy-preserving federated framework with adapter-scoped differential privacy for mental health triage-level intent classification on resource-constrained edge devices. [PDF]
Front Digit HealthM K, Joseph ER, Patil S, Saranya K.
europepmc +1 more source
Spatiotemporal Thermal Modulation and Patterning using a Programmable 1024 Element Microheater Array
Advanced Science, EarlyView.Programmable microheater arrays are essential for a variety of applications. However, large arrays have thus far not been realized. We introduce a programmable 32×$\times$32 microheater array consisting of heating elements – each smaller than 300 μm$\umu{\rm m}$.
Rahul Goyal +3 more
wiley +1 more source
The Possible Significance of Proteomics in Understanding Molecular Mechanisms of Progressive Supranuclear Palsy, Corticobasal Degeneration, Multiple System Atrophy, and Dementia with Lewy Bodies. [PDF]
CellsMadetko-Alster N +3 more
europepmc +1 more source