Results 171 to 180 of about 124,033 (325)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Oral health care's contribution to catastrophic spending in Canada: a descriptive study. [PDF]

Health Policy Open
Proaño D, Allin S, Essue BM, Singhal S, Quiñonez C.   +4 more
europepmc   +1 more source

Participation, growth and social poverty: social capital in a homogeneous society [PDF]

We introduce social capital accumulation into a neoclassical model, showing how it differs from physical and human capital accumulation. We take the view that social capital is crucial to the enjoyment of socially provided goods and that it is mainly ...
Antoci, Angelo, Sacco, Pier Luigi, Vanin, Paolo   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Psychological distress and its associated factors among cancer patients in Nepal: A cross-sectional study. [PDF]

PLOS Ment Health
Acharya A, Bhatta P, Bhatta DD, Shrestha MM, Sapkota VP.   +4 more
europepmc   +1 more source

Introduction: Underlying Concerns and the Field to be Examined [PDF]

, 1982
Dias, Clarence J., Paul, James C.N.
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Household costs, catastrophic out-of-pocket payments and impoverishment related to accessing surgical care in rural Ethiopia. [PDF]

PLoS One
Hailemichael Y, Eshetu T, Timothewos S, Deneke A, Tadesse A, Abdella A, Bekele A, Leather A, Medhin G, Prince M, Hanlon C.   +10 more
europepmc   +1 more source

What should be done in acute emergencies? [PDF]

, 1996
B Harrell-Bond, Cernea, Davis, Harrell-Bond, M Boelaert, Sapir, Van Damme, W Van Damme, W Van Lerberghe   +8 more
core   +2 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source