Results 41 to 50 of about 82,469 (304)

Bayesian Learning for a Class of Priors with Prescribed Marginals [PDF]

, 2006
We present Bayesian updating of an imprecise probability measure, represented by a class of precise multidimensional probability measures. Choice and analysis of our class are motivated by expert interviews that we conducted with modelers in the context ...
Augustin, Thomas, Held, Hermann, Kriegler, Elmar   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Packed Hydrogel Microfibers as Scaffolds Supporting Dynamic Cellular Behavior and Biomaterial Inks in 3D Printing

Advanced Healthcare Materials, EarlyView.
Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal, Remington M. Martinez, Georgia T. Helein, Montserrath G. Ibarra Rivera, Rodolfo Martinez Jr., Jenna L. Sumey, Steven R. Caliari, Christopher B. Highley   +7 more
wiley   +1 more source

Imprecise Reliability Analysis for the Robotic Component Based on Limited Lifetime Data

IEEE Access, 2019
The inverse Weibull (IW) distribution has an ability to model failure rates which are quite common in reliability studies. The three-parameter generalized inverse Weibull (GIW) distribution is a promoted form of the inverse Weibull distribution which is ...
Changhai Li, Yunlong Teng, Zhonglai Wang, Qi Huang   +3 more
doaj   +1 more source

A Slacks-Based Measure Approach for Efficiency Measurement of Recycling Production Systems with Imprecise Data

Journal of Mathematics, 2022
Resource scarcity and environmental degradation have made sustainable resource utilization and environmental protection worldwide. The development of the circular economy is considered an approach for more appropriate economic and environmental ...
Huang-Chu Huang, Fung-Bao Liu, Cheng-Feng Hu   +2 more
doaj   +1 more source

Imprecise compositional data analysis: Alternative statistical methods [PDF]

, 2019
This paper briefly describes statistical methods for analyzing imprecise compositional data that might be elicited from approximate measurement or from expert judgments. Two alternative approaches are discussed: Log-ratio transforms and probability-ratio
Smithson, Michael
core  

Scalable Evaluation of Trajectory Queries Over Imprecise Location Data [PDF]

, 2013
Trajectory queries, which retrieve nearby objects for every point of a given route, can be used to identify alerts of potential threats along a vessel route, or monitor the adjacent rescuers to a travel path. However, the locations of these objects (e.g.,
Xie, X, Yiu, Man Lung, Yiu, ML, Yiu, M, Cheng, R, Cheng, Reynold, Xie, Xike, Lu, Hua, Xie, XK, Lu, H   +9 more
core   +1 more source