The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies [PDF]
Biology, 2023 In this review article, we present the fascinating story of rapamycin (sirolimus), a drug able to induce γ-globin gene expression and increased production of fetal hemoglobin (HbF) in erythroid cells, including primary erythroid precursor cells (ErPCs ...
Roberto Gambari +7 more
doaj +2 more sources
A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs [version 3; peer review: 2 approved] [PDF]
Wellcome Open Research, 2022 Drug repositioning and the relevance of orphan drug designation for β-thalassemia is reviewed. Drug repositioning and similar terms ('drug repurposing', 'drug reprofiling', 'drug redirecting', ‘drug rescue’, ‘drug re-tasking’ and/or 'drug rediscovery ...
Alessia Finotti +6 more
doaj +2 more sources
Beneficial effects of a combined lifestyle intervention for older people in a long-term-care facility on redox balance and endothelial function [PDF]
HeliyonObjective: It has recently been highlighted how a short healthy life-style program (LSP) can improve the functional outcomes of older people admitted to a Long-Term Care (LTC) facility.
Elena Grossini +11 more
doaj +2 more sources
Determinants of attendance in antenatal care clinics in rural settings in Mali and Burkina Faso: a cross-sectional study [PDF]
BMC Pregnancy and ChildbirthBackground Since 2016, the World Health Organization (WHO) has recommended a minimum of eight antenatal care (ANC) contacts during pregnancy, replacing the previous recommendation of four focused ANC visits.
Joel D. Bognini +14 more
doaj +2 more sources
Increasing the uptake of Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) through seasonal malaria chemoprevention channel delivery: protocol of a multicenter cluster randomized implementation trial in Mali and Burkina Faso [PDF]
BMC Public HealthBackground The uptake of Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) remains unacceptably low, with more than two-thirds of pregnant women in sub-Saharan Africa still not accessing the three or more
Kadiatou Koita +15 more
doaj +2 more sources
GROUNDWATER OVEREXPLOITATION OF THE CONTINENTAL INTERCALACRY AQUIFER. A CASE STUDY FROM GHARDAIA, ALGERIA [PDF]
Analele Universităţii din Oradea: Seria Geografie, 2023 Since the late 1999, extensive groundwater extraction within the Sahara aquifer system has been investigated. In this study we analyze the overexploitation of the thermal groundwater stored in the Continental Intercalary aquifer in the Algerian ...
Abdelouahab AMROUNE +2 more
doaj +1 more source
Sostenibilità e imprese per generare il bene comune. Progettualità, Post-Covid 19, Società benefit
Formazione & Insegnamento, 2021 L’attuale situazione planetaria è connotata dalla peggior crisi degli ultimi decenni, molto più dirompente di quella del 2008 in termini di impatto economico, ambientale e sociale.
Alessandra Vischi
doaj +1 more source
NECoM (Numerically Enhanced COnceptual Modelling) of two small Maltese Aquifers: Mizieb and Pwales
Acque Sotterranee, 2021 Two small Maltese aquifers, Mizieb and Pwales, were numerically analyzed to test the existing hydrogeological conceptual model and suggest optimized groundwater monitoring strategies in support of the forthcoming monitoring network coordinated by the ...
Francesca Lotti +11 more
doaj +1 more source
Da Ficarra alla conquista di Palermo: Giuseppe e Ferdinando Malvica
Humanities, 2023 Il contributo intende ricostruire la vicenda umana, sociale ed economica di due esponenti della famiglia Malvica, il capostipite Giuseppe e il nipote di questi, Ferdinando. Vengono qui indagate le origini dello scaltro uomo d’affari che, partito umile da
Vittorio Lorenzo Tumeo, Agostino Zito
doaj +1 more source