Results 1 to 10 of about 34,631 (207)

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies [PDF]

Biology, 2023
In this review article, we present the fascinating story of rapamycin (sirolimus), a drug able to induce γ-globin gene expression and increased production of fetal hemoglobin (HbF) in erythroid cells, including primary erythroid precursor cells (ErPCs ...
Roberto Gambari, Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Alessia Finotti, Maria Rita Gamberini, Marco Prosdocimi   +7 more
doaj   +2 more sources

A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs [version 3; peer review: 2 approved] [PDF]

Wellcome Open Research, 2022
Drug repositioning and the relevance of orphan drug designation for β-thalassemia is reviewed. Drug repositioning and similar terms ('drug repurposing', 'drug reprofiling', 'drug redirecting', ‘drug rescue’, ‘drug re-tasking’ and/or 'drug rediscovery ...
Alessia Finotti, Ilaria Lampronti, Roberto Gambari, Cristina Zuccato, Marco Prosdocimi, Monica Borgatti, Lucia Carmela Cosenza   +6 more
doaj   +2 more sources

Beneficial effects of a combined lifestyle intervention for older people in a long-term-care facility on redox balance and endothelial function [PDF]

Heliyon
Objective: It has recently been highlighted how a short healthy life-style program (LSP) can improve the functional outcomes of older people admitted to a Long-Term Care (LTC) facility.
Elena Grossini, Sakthipryian Venkatesan, Mohammad Mostafa Ola Pour, Andrea Conti, Diego Concina, Annalisa Opizzi, Agatino Sanguedolce, Carmela Rinaldi, Sophia Russotto, Carla Maria Gramaglia, Patrizia Zeppegno, Massimiliano Panella   +11 more
doaj   +2 more sources

Determinants of attendance in antenatal care clinics in rural settings in Mali and Burkina Faso: a cross-sectional study [PDF]

BMC Pregnancy and Childbirth
Background Since 2016, the World Health Organization (WHO) has recommended a minimum of eight antenatal care (ANC) contacts during pregnancy, replacing the previous recommendation of four focused ANC visits.
Joel D. Bognini, Kadiatou Koita, Jean-Baptiste N’takpe, Biébo Bihoun, Mahamadou Dembélé, Oumou Coulibaly, Toussaint Rouamba, Efundem Agboraw, Sirima Traoré, Dario Scaramuzzi, Eve Worrall, Jenny Hill, Kassoum Kayentao, Halidou Tinto, Valérie Briand   +14 more
doaj   +2 more sources

Increasing the uptake of Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) through seasonal malaria chemoprevention channel delivery: protocol of a multicenter cluster randomized implementation trial in Mali and Burkina Faso [PDF]

BMC Public Health
Background The uptake of Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) remains unacceptably low, with more than two-thirds of pregnant women in sub-Saharan Africa still not accessing the three or more
Kadiatou Koita, Joel D. Bognini, Efundem Agboraw, Mahamadou Dembélé, Seydou Yabré, Biébo Bihoun, Oumou Coulibaly, Hamidou Niangaly, Jean-Batiste N’Takpé, Maia Lesosky, Dario Scaramuzzi, Eve Worrall, Jenny Hill, Valérie Briand, Halidou Tinto, Kassoum Kayentao   +15 more
doaj   +2 more sources

Impresa e lavoro sociale [PDF]

, 2009
Kolar, Elisabetta
openaire   +3 more sources

Public trust in sources and channels on judgment accuracy in food safety misinformation with the moderation effect of self‐affirmation: Evidence from the HINTS‐China database

World Medical &Health Policy, Volume 15, Issue 2, Page 148-162, June 2023., 2023
Abstract This paper describes the developmentand introduction of an important new international health survey research program, HINTS‐China, which builds upon HINTS, the established national repeated‐measure US‐based survey that has been used over the past decade to inform national public health policies. The major goal of the first two administrations
Ya Yang, Guoming Yu, Jiabao Pan, Gary L. Kreps   +3 more
wiley   +1 more source

GROUNDWATER OVEREXPLOITATION OF THE CONTINENTAL INTERCALACRY AQUIFER. A CASE STUDY FROM GHARDAIA, ALGERIA [PDF]

Analele Universităţii din Oradea: Seria Geografie, 2023
Since the late 1999, extensive groundwater extraction within the Sahara aquifer system has been investigated. In this study we analyze the overexploitation of the thermal groundwater stored in the Continental Intercalary aquifer in the Algerian ...
Abdelouahab AMROUNE, Redouane MIHOUB, Enrico GUASTALDI   +2 more
doaj   +1 more source

Sostenibilità e imprese per generare il bene comune. Progettualità, Post-Covid 19, Società benefit

Formazione & Insegnamento, 2021
L’attuale situazione planetaria è connotata dalla peggior crisi degli ultimi decenni, molto più dirompente di quella del 2008 in termini di impatto economico, ambientale e sociale.
Alessandra Vischi
doaj   +1 more source

NECoM (Numerically Enhanced COnceptual Modelling) of two small Maltese Aquifers: Mizieb and Pwales

Acque Sotterranee, 2021
Two small Maltese aquifers, Mizieb and Pwales, were numerically analyzed to test the existing hydrogeological conceptual model and suggest optimized groundwater monitoring strategies in support of the forthcoming monitoring network coordinated by the ...
Francesca Lotti, Iacopo Borsi, Enrico Guastaldi, Alessio Barbagli, Paolo Basile, Lorenzo Favaro, Adrian Mallia, Rachel Xuereb, Michael Schembri, Julian Alexander Mamo, Francesco Demichele, Manuel Sapiano   +11 more
doaj   +1 more source