Results 91 to 100 of about 253,842 (268)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Dentists’ Knowledge about Different Impression Techniques for Making Removable Prosthodontics in Isfahan [PDF]
Introduction. One of the most important procedures in making removable prosthodontics, is impression making. This study tried to assess the knowledge of dentists in Isfahan city about different impression techniques for making removable prosthodontics ...
Ramin Moshref, Nina Sadrieh
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Jiamin Li,1,2 Zhenchao Zhong,1,2 Lei Mo1,2 1Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Guangzhou 510631, People’s Republic of China; 2School of Psychology, Center for Studies of Psychological Application ...
Li J, Zhong Z, Mo L
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
POSSIBILITIES AND LIMITATIONS OF DIGITAL IMPRESSIONS IN COMPLETE REMOVABLE DENTURE PROSTHETICS
Relevance. The fabrication of complete dentures for edentulous jaws is a cornerstone of prosthetic dentistry, and retention is a critical factor for clinical success.
O.V. Shemetov
doaj +1 more source
The aim of this contribution is to expand the notion of ecosystems deterioration beyond its necessary but limited materialist sense to include the flattening of their perceptive qualities. Defining the ecosystem as a set of complex relationships between the living subjects and the environment, this essay argues that such relationships include ...
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source

