Measuring Depression Severity With Clinical Global Impression-Severity Scale Scores From Clinical Notes Using Large Language Models: Validation Study. [PDF]
JMIR Form ResLi K +10 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Fabrication of a Maxillary Prosthesis for a Flap-Reconstructed Maxillary Defect Using a 3D-Printed Occlusal Record Base. [PDF]
CureusHattori M +3 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Treatment preferences related to pulpectomy and prosthetic restorations among Lithuanian general dentists and prosthodontists. [PDF]
Acta Odontol ScandAšmankevičiūtė-Lemisnkė V +1 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ultrasound as the Primary Predictor of Perioperative Hemorrhage in Low-to-Moderate Risk Placenta Accreta Spectrum: A Prospective Comparison with MRI in Women with Placenta Previa. [PDF]
Diagnostics (Basel)Lee S +5 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Comment on "Complete-Arch Implant Impression Precision: Digital vs Conventional Techniques". [PDF]
Int Dent JSati DM, Shinde VD, Agarwal C.
europepmc +1 more source