Results 181 to 190 of about 649,205 (307)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Dimensional Stability and Accuracy of Silicone Impression Materials after Ozone Water Disinfection: An In Vitro Study. [PDF]

Front Dent
Kutralanathan A, Chidambaranathan AS, Balasubramaniam M.   +2 more
europepmc   +1 more source

Effect of Surfosept and Deconex® 53 Disinfectant Agents on the Accuracy and Dimensional Stability of Panasil Dental Impression Materials: An Experimental Study. [PDF]

Evid Based Complement Alternat Med, 2021
Alam M, Amini P, Ghaffarpasand A, Dalooei NK, Hadi A, Abbasi K.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of the Effectiveness of Disinfectants on Impression Materials. [PDF]

Cureus
Sivamani Chidambaram R, Rajmohan S, Olive Prasad P, Kalyani D, Mallikarjuna R, Ganiga Channaiah S.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Innovative and Eco-Friendly Natural Fiber Composites for Dental Impression Materials: A Study on Wheat Bran Reinforcement. [PDF]

Polymers (Basel)
Aboamer MA, Almutairi AR, Alassaf A, Alqahtani TM, Almutairi TF, Saijari GN, Mohamed NAR.   +6 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evaluation of the Antibacterial and Antifungal Efficacy of Chitosan Nanoparticles in Irreversible Hydrocolloid Impression Materials: A Cross-Sectional Study. [PDF]

Cureus
Kumawat B, Kumar S, Aggarwal R, Rani G, Choudhary S, Kaur J, Singh AR.   +6 more
europepmc   +1 more source

Comparing the Dimensional Accuracy of Casts Obtained from Two Types of Silicone Impression Materials in Different Impression Techniques and Frequent Times of Cast Preparation. [PDF]

Int J Dent, 2021
Hafezeqoran A, Rahbar M, Koodaryan R, Molaei T.   +3 more
europepmc   +1 more source