Results 211 to 220 of about 535,437 (301)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Respond to: An innovative impression technique for fabrication of a custom-made ocular prosthesis.

Indian J Ophthalmol, 2015
Tripuraneni S, Vadapalli SB, Atluri K, Potluri R.   +3 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Optimizing Denture Stability: A Digital Workflow for Managing Bimaxillary Flabby Ridges in a Complete Denture Fabrication. [PDF]

Clin Case Rep
Garcia E, Jurado CA, Floriani F.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Evaluation of Gingival Sulcus Width Gain After Nd: YAG Laser and Astringent Retraction Paste Using Intraoral and Laboratory STL Analysis: A Pilot Split-Mouth Study. [PDF]

J Clin Med
Bechir ES, Bădărău-Șuster AM, Suciu M, Zamfir AG, Bardocz-Veres Z, Bechir F.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mastering the Flabby Ridge with Precision Impression Techniques in Prosthodontics-A Case Series. [PDF]

J Pharm Bioallied Sci
Chansoria H, Kurhade A, Gupta A, Jayaswal V, Sisodiya M, Gupta S.   +5 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Hybrid Digital Workflow for Accurate Distal Extension Reproduction in Free-End Removable Dental Prosthesis: A Technical Report. [PDF]

Dent J (Basel)
Gonçalves TMSV, Wanghon ZML, da Rocha Bonatto Drummond L, Costa Beber Copetti L, Blummer R, Reis GACD, Pauletto P, Gebler Phillippi A.   +7 more
europepmc   +1 more source