Results 71 to 80 of about 7,141,803 (234)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Research of path planning for polishing robot based on improved genetic algorithm

, 2004
The path planning for traditional polishing robot is teach-play-back method. That is, after adjusting offset errors, the polishing robot repeats the same fixed program in a pre-determined path. Obviously, fixed program makes transferring the robot to new
Qu DK(曲道奎), Guo TY(郭彤颖), Dong ZL(董再励)   +2 more
core  

A guided search genetic algorithm for the university course timetabling problem [PDF]

, 2009
Copyright @ 2009 MISTAThe university course timetabling problem is a combinatorial optimisation problem in which a set of events has to be scheduled in time slots and located in suitable rooms. The design of course timetables for academic institutions is
Yang, S, Jat, SN
core   +4 more sources

Assembly Sequence Optimization based on Improved Genetic Algorithm

Jixie chuandong, 2016
According to the assembly sequence optimization problem of mechanical products,the assembly sequence is used as initial population,and the reference set is added to the genetic algorithm,and the intelligent iterative mechanism of the decentralized search
Yang Wei, Meng Guanjun, Cao Wengang, Xie Kunfeng, Yu Pengfei   +4 more
doaj  

MOTOR TOLERANCE OPTIMIZATION DESIGN BASED ON IMPROVED GENETIC ALGORITHM

Jixie qiangdu, 2021
In order to improve the assembly quality of the motor and reduce the total cost,it is necessary to optimize the design of the tolerances of the key components that form the air gap between the motor stator and the rotor.
ZHANG YongLiang, CHEN Xu, YAO JiaSheng, ZHANG ShuaiShuai   +3 more
doaj  

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Design of supply chain management optimization model based on improved genetic algorithm

Open Computer Science
In the globalized and fiercely competitive market environment, supply chain management plays a pivotal role in the operation and development of enterprises.
Zhang Cheng
doaj   +1 more source