Results 121 to 130 of about 9,334,994 (242)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

FACTORS AFFECTING ADOPTION OF IMPROVED MAIZE SEEDS AND USE OF INORGANIC FERTILIZER FOR MAIZE PRODUCTION IN THE INTERMEDIATE AND LOWLAND ZONES OF TANZANIA [PDF]

open access: yes
This paper examines factors influencing the adoption of improved maize seeds and the use of inorganic fertilizer for maize production by farmers in the intermediate and lowland zones of Tanzania.
Mwangi, Wilfred   +2 more
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Rich food for poor people: Genetically improved tilapia in the Philippines [PDF]

open access: yes
millions fed, food security, Tilapia, Genetically improved, Worldfish, ICLARM,
Yosef, Sivan
core  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Determinants of adoption and intensity of use of balanced nutrient management systems technologies in the northern Guinea savanna of Nigeria [PDF]

open access: yes
As part of a major effort to address soil fertility decline in West Africa, a project on Balanced Nutrient Management Systems (BNMS) has since 2000 been implemented in the northern Guinea savanna (NGS) of Nigeria.
Olanrewaju, Adetunji S.   +7 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Precision Genome Engineering in Human Disease: Expanding Therapeutic Roles of CRISPR Technologies. [PDF]

open access: yesNiger Med J
Ubhenin AE   +5 more
europepmc   +1 more source

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