Results 61 to 70 of about 1,327,800 (294)

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Adapting improvement science tools and routines to build racial equity in out-of-school time STEM spaces

Frontiers in Education
Over the past two decades, networked improvement communities (NICs) have become popular for their collaborative, evidence-based approaches to enduring educational challenges.
Jennifer Iriti, Lori Delale-O'Connor, Jennifer Zoltners Sherer, Talia Stol, Disan Davis, Chris Matthis, Danielle Lowry, Alison Slinskey Legg   +7 more
doaj   +1 more source

The Legitimization of Improvement Science in Academe [PDF]

Journal of Systemics, Cybernetics and Informatics, 2019
This article examines improvement science (Bryk, 2009) against the backdrop of traditional academic research methods. Improvement science is perhaps most closely aligned with design-based implementation research, and is typically applied to networked ...
Casey D. Cobb, Patricia Virella
doaj  

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Preparing improvement teams to manage complex change in a continuous improvement program

Frontiers in Education
This study is a cross-case comparison of three cohorts of teams of educators implementing a continuous improvement program in partnership between a university and a district.
Erin Anderson
doaj   +1 more source

Optogenetic induction of caspase-8 mediated apoptosis by employing Arabidopsis cryptochrome 2

Scientific Reports, 2023
Apoptosis, a programmed cell death mechanism, is a regulatory process controlling cell proliferation as cells undergo demise. Caspase-8 serves as a pivotal apoptosis-inducing factor that initiates the death receptor-mediated apoptosis pathway.
Weiliang Mo, Shengzhong Su, Ruige Shang, Liang Yang, Xuelai Zhao, Chengfeng Wu, Zhenming Yang, He Zhang, Liuming Wu, Yibo Liu, Yun He, Ruipeng Zhang, Zecheng Zuo   +12 more
doaj   +1 more source

Seven propositions of the science of improvement: exploring foundations

, 2014
CONTEXT: The phrase "Science of Improvement" or "Improvement Science" is commonly used today by a range of people and professions to mean different things, creating confusion to those trying to learn about improvement.
Provost, Lloyd P., Perla, Rocco J., Parry, Gareth J.   +2 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Improvement of Disability Rights via Geographic Information Science

, 2020
Rights, legal regulations, and practices often arise from societal and scientific developments, and societal transformations may originate from new legal regulations as well. Basic rights can be re-defined with advancements in science and technology.
Sultan Kocaman, Nadire Ozdemir
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source