Results 61 to 70 of about 136,813 (264)
Controller of sequential synchronous reception
Технологія та конструювання в електронній апаратурі, 2004 The interaction of a microcomputer with external devices (ED) is carried out through an ED controller. The controller includes a shift register, a three-bit binary counter, and a buffer register.
G. V. Kutsenko
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Lyapunov type inequalities and their applications for quasilinear impulsive systems
Journal of Taibah University for Science, 2019 A novel Lyapunov-type inequality for Dirichlet problem associated with the quasilinear impulsive system involving the $(p_j, q_j) $-Laplacian operator for j=1,2 is obtained.
Zeynep Kayar
doaj +1 more source
Frontiers in Human Neuroscience, 2015 Being able to stop (or inhibit) an action rapidly as in a stop-signal task is an essential human ability. Previous studies showed that when a pre-stimulus cue warned of the possible need to stop a response in an upcoming trial, participants’ response ...
Benjamin eXu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Noise and Health, 2011 Damage-risk criteria (DRC) for noise exposures are designed to protect 95% of the exposed populations from hearing injuries caused by those noise exposures. The current DRC used by the US military follows OSHA guidelines for continuous noise. The current
William A Ahroon +2 more
doaj +1 more source
Dopamine‐agonists and impulsivity in Parkinson's disease: Impulsive choices vs. impulsive actions
Human Brain Mapping, 2013 AbstractThe control of impulse behavior is a multidimensional concept subdivided into separate subcomponents, which are thought to represent different underlying mechanisms due to either disinhibitory processes or poor decision‐making. In patients with Parkinson's disease (PD), dopamine‐agonist (DA) therapy has been associated with increased impulsive ...
Francesca, Antonelli +7 more
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source