Results 51 to 60 of about 689,555 (336)

Clinical psychology of Internet addiction: a review of its conceptualization, prevalence, neuronal processes, and implications for treatment [PDF]

, 2015
Research into Internet addiction (IA) has grown rapidly over the last decade. The topic has generated a great deal of debate, particularly in relation to how IA can be defined conceptually as well as the many methodological limitations.
Griffiths, MD, Kuss, DJ, Pontes, HM
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Bad Nature, Bad Nurture, and Testimony Regarding MAOA and SLC6A4 Genotyping in Murder Trials [PDF]

, 2007
Recent research—in which subjects were studied longitudinally from childhood until adulthood—has started to clarify how a child’s environment and genetic makeup interact to create a violent adolescent or adult.
Bernet, William, Farahany, Nita A., Montgomery, Stephen A., Vnencak-Jones, Cindy L.   +3 more
core   +2 more sources

Social cognition in patients with Parkinson's disease and impulse control disorders [PDF]

Medicinski Podmladak
Introduction: Parkinson's disease (PD) is a slowly progressive degenerative disease characterized by tremors, rigidity, bradykinesia, and postural instability. The pathogenesis of PD is characterized by neurodegeneration of dopaminergic neurons.
Pančurov Aleksandra, Putniković Dunja, Dragaševič-Mišković Nataša   +2 more
doaj   +1 more source

Can disordered mobile phone use be considered a behavioral addiction? An update on current evidence and a comprehensive model for future research [PDF]

, 2015
Despite the many positive outcomes, excessive mobile phone use is now often associated with potentially harmful and/or disturbing behaviors (e.g., symptoms of deregulated use, negative impact on various aspects of daily life such as relationship problems,
A Bianchi, A Blaszczynski, A Ehrenberg, A Lepp, AE Goudriaan, AL Dir, ALS King, ALS King, Annemarie Nicol, BS Fjeldsoe, C Augner, CF Yen, CM Kokkinos, D Kim, DJ Stein, F Zheng, G Dong, H Blake, H Khang, J Billieux, J Billieux, J Billieux, J Billieux, J Billieux, J Billieux, J Weafer, J Weinstock, J-Y Mok, JA Roberts, JH Ha, JM Violanti, L Leung, M Chóliz, M Kwon, M Littel, M Salehan, M Toda, MD Griffiths, MD Griffiths, MP White, NM Petry, O Lopez-Fernandez, P Smetaniuk, RC Nickerson, RJ Holst Van, S Butt, S Thomée, SM Groman, T Igarashi, X Carbonell, X Lu, X Lu, Y Barkana, Y-H Lin, Y-K Lee, Z-H Zhou   +55 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Examining the presence and frequency of impulse control disorders in Wilson's disease [PDF]

Medicinski Podmladak
Introduction: Wilson's disease is a rare, hereditary disease, which leads to the accumulation of copper, primarily in the liver and brain, due to the impossibility of its excretion from the body.
Nikolić Ana, Mladenović Danilo, Marković Vladana   +2 more
doaj   +1 more source

The impact of cognitive training in substance use disorder: the effect of working memory training on impulse control in methamphetamine users

Psychopharmacology, 2017
ObjectivesImpulsivity is a vulnerability trait for poor self-regulation in substance use disorder (SUD). Working memory (WM) training improves impulsivity and self-regulation in psychiatric disorders.
Samantha J. Brooks, L. Wiemerslage, K. Burch, Sal Maiorana, E. Cocolas, H. Schiöth, K. Kamaloodien, D. Stein   +7 more
semanticscholar   +1 more source

The classification of substance and behavioural addictions: A preliminary investigation [PDF]

, 2012
The term addiction has been used to refer to impaired control over substance use for several centuries however recently there has been a shift toward using this term in the context of non-substance use disorders, such as pathological gambling.
McLaughlan, Andre David, Starkey, Nicola J.   +1 more
core   +1 more source