Results 61 to 70 of about 519,674 (299)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

An nth Harmonic Current Suppression Method Based on the Impulse Current PWM Technique for a Multi-Phase Permanent Magnet Synchronous Motor Fed with a Current Source Inverter

open access: yesEnergies, 2022
Among the existing harmonic current suppression methods, it is difficult and complicated to suppress any nth harmonic current accurately for multi-phase permanent magnet synchronous motors (PMSMs).
Chao Chen   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Transcranial direct current brain stimulation decreases impulsivity in ADHD [PDF]

open access: yesBrain Stimulation, 2018
Impulsivity is a core deficit in attention deficit hyperactivity disorder (ADHD). Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits and could enhance DLPFC activity, leading to improved impulse control in ADHD.Hypothesis: We predicted 2.0 mA anodal ...
Cheyenne, Allenby   +7 more
openaire   +2 more sources

Alternate-continuous-control systems with double-impulse

open access: yesAdvances in Difference Equations, 2017
We propose a mathematical model that can control the stability of an unstable system. Periodicity is an important feature of the system. We add a continuous control to the first half of each period of the system and then add an impulse control J1 at the ...
Xiang Hu   +3 more
doaj   +1 more source

Voltage Distribution Analysis of High Coupled Split Reactor in 500 kV AC Fault Current Limiter

open access: yesIEEE Access, 2020
With the increase of short circuit current, measures should be taken to reduce the impact. Among various measures, a new technique to interrupt or limit current is proposed and applied to power grid based on high coupled split reactor (HCSR).
Kaijian Wu   +8 more
doaj   +1 more source

Exchange Current Corrections to Neutrino--Nucleus Scattering [PDF]

open access: yes, 1994
Relativistic exchange current corrections to neutrino--nucleus cross sections are presented assuming non--vanishing strange quark form factors for the constituent nucleons.
C. J. Horowitz   +26 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

An audio FIR-DAC in a BCD process for high power Class-D amplifiers [PDF]

open access: yes, 2005
A 322 coefficient semi-digital FIR-DAC using a 1-bit PWM input signal was designed and implemented in a high voltage, audio power bipolar CMOS DMOS (BCD) process. This facilitates digital input signals for an analog class-D amplifier in BCD.
Annema, A.J.   +5 more
core   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

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